BRD-A10715913_-666_ASC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

132 genes differentially expressed following the BRD-A10715913_-666_ASC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CCND2 cyclin D2
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD200 CD200 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CELF2 CUGBP, Elav-like family member 2
CPA3 carboxypeptidase A3 (mast cell)
CPB1 carboxypeptidase B1 (tissue)
CREM cAMP responsive element modulator
DOCK9 dedicator of cytokinesis 9
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
HES1 hes family bHLH transcription factor 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HSPA2 heat shock 70kDa protein 2
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
JCHAIN joining chain of multimeric IgA and IgM
MMP12 matrix metallopeptidase 12
MYB v-myb avian myeloblastosis viral oncogene homolog
PDE2A phosphodiesterase 2A, cGMP-stimulated
POSTN periostin, osteoblast specific factor
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
RPP38 ribonuclease P/MRP 38kDa subunit
S100P S100 calcium binding protein P
SCN3B sodium channel, voltage gated, type III beta subunit
SCRN1 secernin 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SPARCL1 SPARC-like 1 (hevin)
STAP2 signal transducing adaptor family member 2
STXBP2 syntaxin binding protein 2
SULF1 sulfatase 1
TDRD12 tudor domain containing 12
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TJP1 tight junction protein 1
TMEM30B transmembrane protein 30B
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACTB actin, beta
ACTN1 actinin, alpha 1
AK4 adenylate kinase 4
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALCAM activated leukocyte cell adhesion molecule
ALOX5 arachidonate 5-lipoxygenase
ANPEP alanyl (membrane) aminopeptidase
ANXA5 annexin A5
AP2S1 adaptor-related protein complex 2, sigma 1 subunit
ATP5I ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E
BIN1 bridging integrator 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C1QB complement component 1, q subcomponent, B chain
CALU calumenin
CAV2 caveolin 2
CD151 CD151 molecule (Raph blood group)
CD47 CD47 molecule
CIRBP cold inducible RNA binding protein
CLTC clathrin, heavy chain (Hc)
COTL1 coactosin-like F-actin binding protein 1
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous)
CRYAB crystallin, alpha B
CSRP1 cysteine and glycine-rich protein 1
CST3 cystatin C
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYB5A cytochrome b5 type A (microsomal)
DCN decorin
DDT D-dopachrome tautomerase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEGS1 delta(4)-desaturase, sphingolipid 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELOVL5 ELOVL fatty acid elongase 5
FABP7 fatty acid binding protein 7, brain
FADS1 fatty acid desaturase 1
FAM13A family with sequence similarity 13, member A
FAM162A family with sequence similarity 162, member A
GLRX glutaredoxin (thioltransferase)
GNAS GNAS complex locus
GRN granulin
HBB hemoglobin, beta
HN1 hematological and neurological expressed 1
HSPB1 heat shock 27kDa protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INHBB inhibin, beta B
ITGB5 integrin, beta 5
LAMB1 laminin, beta 1
LHFP lipoma HMGIC fusion partner
LY6E lymphocyte antigen 6 complex, locus E
MAP1B microtubule-associated protein 1B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MPC2 mitochondrial pyruvate carrier 2
MRPL12 mitochondrial ribosomal protein L12
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NRN1 neuritin 1
PCNA proliferating cell nuclear antigen
PCOLCE procollagen C-endopeptidase enhancer
PEBP1 phosphatidylethanolamine binding protein 1
PHGDH phosphoglycerate dehydrogenase
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPIE peptidylprolyl isomerase E (cyclophilin E)
PRDX4 peroxiredoxin 4
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTN pleiotrophin
RND3 Rho family GTPase 3
RPS4Y1 ribosomal protein S4, Y-linked 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCPEP1 serine carboxypeptidase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC22A18 solute carrier family 22, member 18
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SORBS3 sorbin and SH3 domain containing 3
SRPX sushi-repeat containing protein, X-linked
STEAP3 STEAP family member 3, metalloreductase
STK17A serine/threonine kinase 17a
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM45A transmembrane protein 45A
TSPAN4 tetraspanin 4
TXLNA taxilin alpha
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
USP22 ubiquitin specific peptidase 22
UXT ubiquitously-expressed, prefoldin-like chaperone
VKORC1 vitamin K epoxide reductase complex, subunit 1
YBX1 Y box binding protein 1