BRD-A10523515_HY-11000_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

96 genes differentially expressed following the BRD-A10523515_HY-11000_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSF2 acyl-CoA synthetase family member 2
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADIRF adipogenesis regulatory factor
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
C8ORF4 chromosome 8 open reading frame 4
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRIP1 cysteine-rich protein 1 (intestinal)
CST3 cystatin C
E2F2 E2F transcription factor 2
FGB fibrinogen beta chain
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GDF15 growth differentiation factor 15
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX2 glutathione peroxidase 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HOXB7 homeobox B7
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IRS2 insulin receptor substrate 2
KYNU kynureninase
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MBOAT7 membrane bound O-acyltransferase domain containing 7
MICB MHC class I polypeptide-related sequence B
MITF microphthalmia-associated transcription factor
MUC4 mucin 4, cell surface associated
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDE1A phosphodiesterase 1A, calmodulin-dependent
PLAT plasminogen activator, tissue
PON2 paraoxonase 2
PRAME preferentially expressed antigen in melanoma
PSAT1 phosphoserine aminotransferase 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
REG1A regenerating islet-derived 1 alpha
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SGK1 serum/glucocorticoid regulated kinase 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC44A4 solute carrier family 44, member 4
SOX4 SRY (sex determining region Y)-box 4
SRSF7 serine/arginine-rich splicing factor 7
STEAP1 six transmembrane epithelial antigen of the prostate 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
TM4SF1 transmembrane 4 L six family member 1
TMEM47 transmembrane protein 47
TSC22D1 TSC22 domain family, member 1

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACTA1 actin, alpha 1, skeletal muscle
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ASPN asporin
AUTS2 autism susceptibility candidate 2
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCL4 chemokine (C-C motif) ligand 4
CCNA1 cyclin A1
CEP57 centrosomal protein 57kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLTC clathrin, heavy chain (Hc)
COL5A1 collagen, type V, alpha 1
CORO1A coronin, actin binding protein, 1A
CPA3 carboxypeptidase A3 (mast cell)
CRABP1 cellular retinoic acid binding protein 1
DPT dermatopontin
DPYSL3 dihydropyrimidinase-like 3
ELN elastin
FABP7 fatty acid binding protein 7, brain
FRS2 fibroblast growth factor receptor substrate 2
GAL galanin/GMAP prepropeptide
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IL1B interleukin 1, beta
INSR insulin receptor
ISOC1 isochorismatase domain containing 1
LAPTM5 lysosomal protein transmembrane 5
LGALS8 lectin, galactoside-binding, soluble, 8
LTF lactotransferrin
MFAP2 microfibrillar-associated protein 2
MXRA5 matrix-remodelling associated 5
NEB nebulin
NELL2 NEL-like 2 (chicken)
PRKX protein kinase, X-linked
PWP1 PWP1 homolog (S. cerevisiae)
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLN sarcolipin
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
STAB1 stabilin 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TGFB3 transforming growth factor, beta 3
THBS4 thrombospondin 4
TTN titin