BRD-A10523515_GSK-429286A_MCF7_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

81 genes differentially expressed following the BRD-A10523515_GSK-429286A_MCF7_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ACP5 acid phosphatase 5, tartrate resistant
ACTC1 actin, alpha, cardiac muscle 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AREG amphiregulin
CASP10 caspase 10, apoptosis-related cysteine peptidase
COLEC12 collectin sub-family member 12
DDIT4 DNA-damage-inducible transcript 4
EGFL6 EGF-like-domain, multiple 6
F12 coagulation factor XII (Hageman factor)
FAM134B family with sequence similarity 134, member B
GATA6 GATA binding protein 6
GLUL glutamate-ammonia ligase
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL32 interleukin 32
KIF5C kinesin family member 5C
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KRT14 keratin 14, type I
LAPTM5 lysosomal protein transmembrane 5
LGALS8 lectin, galactoside-binding, soluble, 8
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
MMP2 matrix metallopeptidase 2
NAMPT nicotinamide phosphoribosyltransferase
NEB nebulin
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLK2 polo-like kinase 2
REEP1 receptor accessory protein 1
S100A1 S100 calcium binding protein A1
S100A8 S100 calcium binding protein A8
SCARB1 scavenger receptor class B, member 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLPI secretory leukocyte peptidase inhibitor
SORBS2 sorbin and SH3 domain containing 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SUB1 SUB1 homolog (S. cerevisiae)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TMEM176B transmembrane protein 176B
TXNIP thioredoxin interacting protein
UBE3B ubiquitin protein ligase E3B
USP6NL USP6 N-terminal like
WDR7 WD repeat domain 7
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ADD3 adducin 3 (gamma)
C8ORF4 chromosome 8 open reading frame 4
CALU calumenin
CHN1 chimerin 1
CRISP3 cysteine-rich secretory protein 3
CXCL14 chemokine (C-X-C motif) ligand 14
DHRS2 dehydrogenase/reductase (SDR family) member 2
DMTF1 cyclin D binding myb-like transcription factor 1
EDNRB endothelin receptor type B
EFHD1 EF-hand domain family, member D1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EXOSC4 exosome component 4
FAIM Fas apoptotic inhibitory molecule
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
IGFBP7 insulin-like growth factor binding protein 7
ITGAV integrin, alpha V
JAG1 jagged 1
MAL mal, T-cell differentiation protein
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NLRP2 NLR family, pyrin domain containing 2
OLFM1 olfactomedin 1
PFN2 profilin 2
TBX2 T-box 2
TOB1 transducer of ERBB2, 1
WBP5 WW domain binding protein 5
XIST X inactive specific transcript (non-protein coding)
ZBTB10 zinc finger and BTB domain containing 10