BRD-A10523515_GSK-429286A_MCF7_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

83 genes differentially expressed following the BRD-A10523515_GSK-429286A_MCF7_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCK3 aarF domain containing kinase 3
C3 complement component 3
CA2 carbonic anhydrase II
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CLU clusterin
CST3 cystatin C
CSTA cystatin A (stefin A)
DUSP10 dual specificity phosphatase 10
ELOVL2 ELOVL fatty acid elongase 2
F12 coagulation factor XII (Hageman factor)
FADS1 fatty acid desaturase 1
FHL1 four and a half LIM domains 1
FOXC1 forkhead box C1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GLUL glutamate-ammonia ligase
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPX3 glutathione peroxidase 3
HP haptoglobin
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
KRT13 keratin 13, type I
KRT15 keratin 15, type I
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LTF lactotransferrin
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MBNL2 muscleblind-like splicing regulator 2
NDRG2 NDRG family member 2
NPY1R neuropeptide Y receptor Y1
P3H2 prolyl 3-hydroxylase 2
PDLIM5 PDZ and LIM domain 5
PERP PERP, TP53 apoptosis effector
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RHOB ras homolog family member B
RTN1 reticulon 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SFRP1 secreted frizzled-related protein 1
SLPI secretory leukocyte peptidase inhibitor
SORBS2 sorbin and SH3 domain containing 2
TACSTD2 tumor-associated calcium signal transducer 2
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TF transferrin
TFF1 trefoil factor 1
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM2 tripartite motif containing 2
TSPYL5 TSPY-like 5
TTN titin
WEE1 WEE1 G2 checkpoint kinase
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
BPHL biphenyl hydrolase-like (serine hydrolase)
C1ORF54 chromosome 1 open reading frame 54
C6ORF62 chromosome 6 open reading frame 62
CBX3 chromobox homolog 3
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPNMB glycoprotein (transmembrane) nmb
GRB10 growth factor receptor-bound protein 10
HOXC10 homeobox C10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL7R interleukin 7 receptor
ISG15 ISG15 ubiquitin-like modifier
JCHAIN joining chain of multimeric IgA and IgM
KCNK1 potassium channel, two pore domain subfamily K, member 1
LAGE3 L antigen family, member 3
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
RGS1 regulator of G-protein signaling 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SKP1 S-phase kinase-associated protein 1
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SST somatostatin
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TUBB2A tubulin, beta 2A class IIa
VNN1 vanin 1