BRD-A10523515_GSK-429286A_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-A10523515_GSK-429286A_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AVPI1 arginine vasopressin-induced 1
BCL6 B-cell CLL/lymphoma 6
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
COLEC12 collectin sub-family member 12
CTSH cathepsin H
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ETV5 ets variant 5
GRWD1 glutamate-rich WD repeat containing 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IGFBP5 insulin-like growth factor binding protein 5
IGFBP6 insulin-like growth factor binding protein 6
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LEPR leptin receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LY6E lymphocyte antigen 6 complex, locus E
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
NRIP1 nuclear receptor interacting protein 1
PENK proenkephalin
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPS4Y1 ribosomal protein S4, Y-linked 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRSF6 serine/arginine-rich splicing factor 6
TCAF1 TRPM8 channel-associated factor 1
TCTA T-cell leukemia translocation altered
TIAM1 T-cell lymphoma invasion and metastasis 1
TRAPPC6A trafficking protein particle complex 6A

decreased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
AK4 adenylate kinase 4
ALB albumin
ALDOB aldolase B, fructose-bisphosphate
ANK2 ankyrin 2, neuronal
AQP1 aquaporin 1 (Colton blood group)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
CCL2 chemokine (C-C motif) ligand 2
CD58 CD58 molecule
COL11A1 collagen, type XI, alpha 1
CRIP2 cysteine-rich protein 2
CST1 cystatin SN
CYCS cytochrome c, somatic
DEPTOR DEP domain containing MTOR-interacting protein
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EGF epidermal growth factor
FABP1 fatty acid binding protein 1, liver
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FILIP1L filamin A interacting protein 1-like
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IER3 immediate early response 3
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
ISOC1 isochorismatase domain containing 1
KNG1 kininogen 1
KRT20 keratin 20, type I
MAGEA3 melanoma antigen family A3
MAL mal, T-cell differentiation protein
MMP10 matrix metallopeptidase 10
MSMO1 methylsterol monooxygenase 1
MYB v-myb avian myeloblastosis viral oncogene homolog
MYL9 myosin, light chain 9, regulatory
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
PNP purine nucleoside phosphorylase
PODXL podocalyxin-like
PSAT1 phosphoserine aminotransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SQLE squalene epoxidase
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
THBS2 thrombospondin 2
TNIP1 TNFAIP3 interacting protein 1
TXNDC9 thioredoxin domain containing 9
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28