BRD-A10420615_Cyclopiazonic Acid_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

104 genes differentially expressed following the BRD-A10420615_Cyclopiazonic Acid_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AARS alanyl-tRNA synthetase
ACSL3 acyl-CoA synthetase long-chain family member 3
AGR2 anterior gradient 2
AKR1C2 aldo-keto reductase family 1, member C2
ANXA3 annexin A3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
C6ORF48 chromosome 6 open reading frame 48
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CTH cystathionine gamma-lyase
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSP desmoplakin
EPRS glutamyl-prolyl-tRNA synthetase
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GARS glycyl-tRNA synthetase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IFRD1 interferon-related developmental regulator 1
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
KLF5 Kruppel-like factor 5 (intestinal)
LDLR low density lipoprotein receptor
LTF lactotransferrin
MARS methionyl-tRNA synthetase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLPH melanophilin
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC5B mucin 5B, oligomeric mucus/gel-forming
NEBL nebulette
NRIP1 nuclear receptor interacting protein 1
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PHGDH phosphoglycerate dehydrogenase
PSAT1 phosphoserine aminotransferase 1
RNASET2 ribonuclease T2
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SFN stratifin
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRRM2 serine/arginine repetitive matrix 2
STC2 stanniocalcin 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TOB1 transducer of ERBB2, 1
TRIB3 tribbles pseudokinase 3
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
XPOT exportin, tRNA
ZNF24 zinc finger protein 24

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
CD44 CD44 molecule (Indian blood group)
CD93 CD93 molecule
CHEK1 checkpoint kinase 1
CLEC2B C-type lectin domain family 2, member B
CTGF connective tissue growth factor
CXCL10 chemokine (C-X-C motif) ligand 10
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FSD1 fibronectin type III and SPRY domain containing 1
GTF2A2 general transcription factor IIA, 2, 12kDa
HOPX HOP homeobox
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
LGALS1 lectin, galactoside-binding, soluble, 1
LMNB1 lamin B1
MDFIC MyoD family inhibitor domain containing
MEX3D mex-3 RNA binding family member D
MMP7 matrix metallopeptidase 7
NT5DC2 5'-nucleotidase domain containing 2
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PAX6 paired box 6
PBX1 pre-B-cell leukemia homeobox 1
PDE4B phosphodiesterase 4B, cAMP-specific
PEA15 phosphoprotein enriched in astrocytes 15
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROM1 prominin 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SNX10 sorting nexin 10
STMN1 stathmin 1
TGM2 transglutaminase 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TYMS thymidylate synthetase
VCAN versican
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZEB1 zinc finger E-box binding homeobox 1