BRD-A10420615_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-A10420615_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ARF4 ADP-ribosylation factor 4
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL1 ADP-ribosylation factor-like 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPH aspartate beta-hydroxylase
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
BET1 Bet1 golgi vesicular membrane trafficking protein
BHLHE41 basic helix-loop-helix family, member e41
CALR calreticulin
CALU calumenin
CKAP4 cytoskeleton-associated protein 4
CLDND1 claudin domain containing 1
COPG1 coatomer protein complex, subunit gamma 1
CREB3L2 cAMP responsive element binding protein 3-like 2
CRELD2 cysteine-rich with EGF-like domains 2
CTH cystathionine gamma-lyase
CTSS cathepsin S
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EPRS glutamyl-prolyl-tRNA synthetase
FICD FIC domain containing
FKBP11 FK506 binding protein 11, 19 kDa
FKBP14 FK506 binding protein 14, 22 kDa
FNDC3B fibronectin type III domain containing 3B
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GORASP2 golgi reassembly stacking protein 2, 55kDa
H1F0 H1 histone family, member 0
HDLBP high density lipoprotein binding protein
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HYOU1 hypoxia up-regulated 1
IFNGR1 interferon gamma receptor 1
KCTD5 potassium channel tetramerization domain containing 5
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LDLR low density lipoprotein receptor
LPAR6 lysophosphatidic acid receptor 6
MANF mesencephalic astrocyte-derived neurotrophic factor
MMP9 matrix metallopeptidase 9
MYDGF myeloid-derived growth factor
NFIL3 nuclear factor, interleukin 3 regulated
NT5E 5'-nucleotidase, ecto (CD73)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
P4HB prolyl 4-hydroxylase, beta polypeptide
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDIA4 protein disulfide isomerase family A, member 4
PDZK1IP1 PDZK1 interacting protein 1
PEG3 paternally expressed 3
PGM3 phosphoglucomutase 3
PHGDH phosphoglycerate dehydrogenase
PPAP2B phosphatidic acid phosphatase type 2B
PPIB peptidylprolyl isomerase B (cyclophilin B)
PSAT1 phosphoserine aminotransferase 1
RABAC1 Rab acceptor 1 (prenylated)
RAD9A RAD9 homolog A (S. pombe)
RCAN1 regulator of calcineurin 1
S100A12 S100 calcium binding protein A12
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SDF2L1 stromal cell-derived factor 2-like 1
SEC23B Sec23 homolog B (S. cerevisiae)
SEC24D SEC24 family member D
SEC63 SEC63 homolog (S. cerevisiae)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC35B1 solute carrier family 35, member B1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOD2 superoxide dismutase 2, mitochondrial
SSPN sarcospan
SSR1 signal sequence receptor, alpha
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
SST somatostatin
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM39A transmembrane protein 39A
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNNT1 troponin T type 1 (skeletal, slow)
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
TXNDC15 thioredoxin domain containing 15
TXNIP thioredoxin interacting protein
UFM1 ubiquitin-fold modifier 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
AKR1C2 aldo-keto reductase family 1, member C2
ALCAM activated leukocyte cell adhesion molecule
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCND1 cyclin D1
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
DDB2 damage-specific DNA binding protein 2, 48kDa
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
GOLGA8A golgin A8 family, member A
HES1 hes family bHLH transcription factor 1
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
KIF14 kinesin family member 14
KRT19 keratin 19, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LEPR leptin receptor
MTF2 metal response element binding transcription factor 2
PDGFA platelet-derived growth factor alpha polypeptide
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCD protein kinase C, delta
RBP1 retinol binding protein 1, cellular
RPIA ribose 5-phosphate isomerase A
SORD sorbitol dehydrogenase
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TUBB2A tubulin, beta 2A class IIa
VAMP8 vesicle-associated membrane protein 8
WWP1 WW domain containing E3 ubiquitin protein ligase 1