BRD-A10420615_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-A10420615_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ACLY ATP citrate lyase
ACSL1 acyl-CoA synthetase long-chain family member 1
ADGRG2 adhesion G protein-coupled receptor G2
AGR2 anterior gradient 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDOC aldolase C, fructose-bisphosphate
ANKRD10 ankyrin repeat domain 10
AQP3 aquaporin 3 (Gill blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
BEX1 brain expressed, X-linked 1
C14ORF1 chromosome 14 open reading frame 1
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CD46 CD46 molecule, complement regulatory protein
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CFB complement factor B
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHGB chromogranin B
CLIC4 chloride intracellular channel 4
CSRP1 cysteine and glycine-rich protein 1
CST3 cystatin C
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DEGS1 delta(4)-desaturase, sphingolipid 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DHRS7 dehydrogenase/reductase (SDR family) member 7
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EBP emopamil binding protein (sterol isomerase)
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EFNA1 ephrin-A1
ELOVL5 ELOVL fatty acid elongase 5
ELOVL6 ELOVL fatty acid elongase 6
ENO2 enolase 2 (gamma, neuronal)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM134B family with sequence similarity 134, member B
FDPS farnesyl diphosphate synthase
FGFBP1 fibroblast growth factor binding protein 1
G0S2 G0/G1 switch 2
GANAB glucosidase, alpha; neutral AB
GLRX glutaredoxin (thioltransferase)
GNAS GNAS complex locus
HACD1 3-hydroxyacyl-CoA dehydratase 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST2H2BE histone cluster 2, H2be
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOOK2 hook microtubule-tethering protein 2
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
INSIG1 insulin induced gene 1
KDSR 3-ketodihydrosphingosine reductase
LDLR low density lipoprotein receptor
LIPA lipase A, lysosomal acid, cholesterol esterase
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MMP7 matrix metallopeptidase 7
MSMO1 methylsterol monooxygenase 1
NEFL neurofilament, light polypeptide
NLGN4X neuroligin 4, X-linked
NPY1R neuropeptide Y receptor Y1
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM1 olfactomedin 1
OLFM4 olfactomedin 4
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCSK1 proprotein convertase subtilisin/kexin type 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PENK proenkephalin
PHGDH phosphoglycerate dehydrogenase
PNMA2 paraneoplastic Ma antigen 2
PRAF2 PRA1 domain family, member 2
PRDX2 peroxiredoxin 2
PRUNE2 prune homolog 2 (Drosophila)
PSAT1 phosphoserine aminotransferase 1
REEP1 receptor accessory protein 1
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG2 secretogranin II
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC38A2 solute carrier family 38, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SQLE squalene epoxidase
SREBF2 sterol regulatory element binding transcription factor 2
STXBP1 syntaxin binding protein 1
SV2C synaptic vesicle glycoprotein 2C
SYT1 synaptotagmin I
TAC1 tachykinin, precursor 1
THBS2 thrombospondin 2
TIMP1 TIMP metallopeptidase inhibitor 1
TRIB2 tribbles pseudokinase 2
TRIM2 tripartite motif containing 2
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TSPAN1 tetraspanin 1
TSPAN31 tetraspanin 31
TSPAN7 tetraspanin 7
WARS tryptophanyl-tRNA synthetase
WASF1 WAS protein family, member 1
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
ANPEP alanyl (membrane) aminopeptidase
BTG3 BTG family, member 3
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCDC85B coiled-coil domain containing 85B
CDC42 cell division cycle 42
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DMD dystrophin
EGFR epidermal growth factor receptor
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYBPC1 myosin binding protein C, slow type
NUSAP1 nucleolar and spindle associated protein 1
PDGFC platelet derived growth factor C
PLK1 polo-like kinase 1
RGS1 regulator of G-protein signaling 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX9 SRY (sex determining region Y)-box 9
TCF4 transcription factor 4