BRD-A10420615_-666_ASC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

72 genes differentially expressed following the BRD-A10420615_-666_ASC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMIGO2 adhesion molecule with Ig-like domain 2
C3 complement component 3
CD40 CD40 molecule, TNF receptor superfamily member 5
CYBA cytochrome b-245, alpha polypeptide
FZD7 frizzled class receptor 7
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRT18 keratin 18, type I
NNMT nicotinamide N-methyltransferase
NUCB2 nucleobindin 2
NUP210 nucleoporin 210kDa
PDLIM5 PDZ and LIM domain 5
PTGIS prostaglandin I2 (prostacyclin) synthase
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFN stratifin
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC35B1 solute carrier family 35, member B1
SPAG4 sperm associated antigen 4
SPINT2 serine peptidase inhibitor, Kunitz type, 2
TGFA transforming growth factor, alpha
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
WFDC2 WAP four-disulfide core domain 2
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
BIRC5 baculoviral IAP repeat containing 5
CDC20 cell division cycle 20
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP4 dual specificity phosphatase 4
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM171A1 family with sequence similarity 171, member A1
GLIPR1 GLI pathogenesis-related 1
GSTT1 glutathione S-transferase theta 1
HEPH hephaestin
HES1 hes family bHLH transcription factor 1
HMGB2 high mobility group box 2
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
IL13RA2 interleukin 13 receptor, alpha 2
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KLF5 Kruppel-like factor 5 (intestinal)
LMNB1 lamin B1
LPL lipoprotein lipase
LRRC41 leucine rich repeat containing 41
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MELK maternal embryonic leucine zipper kinase
MPO myeloperoxidase
MTERF3 mitochondrial transcription termination factor 3
ODC1 ornithine decarboxylase 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLBD1 phospholipase B domain containing 1
PRKCB protein kinase C, beta
RANBP1 RAN binding protein 1
RHOBTB3 Rho-related BTB domain containing 3
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100P S100 calcium binding protein P
SELENBP1 selenium binding protein 1
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TOP2A topoisomerase (DNA) II alpha 170kDa
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta