BRD-A10355991_Norketamine hydrochloride_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

111 genes differentially expressed following the BRD-A10355991_Norketamine hydrochloride_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHR aryl hydrocarbon receptor
CD44 CD44 molecule (Indian blood group)
CFDP1 craniofacial development protein 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COG7 component of oligomeric golgi complex 7
CRYM crystallin, mu
CXCR4 chemokine (C-X-C motif) receptor 4
CYBB cytochrome b-245, beta polypeptide
DEGS1 delta(4)-desaturase, sphingolipid 1
DLK1 delta-like 1 homolog (Drosophila)
DMXL2 Dmx-like 2
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
EXPH5 exophilin 5
EXT1 exostosin glycosyltransferase 1
FTH1 ferritin, heavy polypeptide 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GCLC glutamate-cysteine ligase, catalytic subunit
GNS glucosamine (N-acetyl)-6-sulfatase
GRB7 growth factor receptor-bound protein 7
H2AFV H2A histone family, member V
HBD hemoglobin, delta
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HOMER3 homer scaffolding protein 3
HOXB2 homeobox B2
IGFBP5 insulin-like growth factor binding protein 5
IPO13 importin 13
LGALS2 lectin, galactoside-binding, soluble, 2
LOC100505650 uncharacterized LOC100505650
LYZ lysozyme
MAOA monoamine oxidase A
MNDA myeloid cell nuclear differentiation antigen
MSMB microseminoprotein, beta-
MUC4 mucin 4, cell surface associated
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NT5DC2 5'-nucleotidase domain containing 2
NUPR1 nuclear protein, transcriptional regulator, 1
NVL nuclear VCP-like
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PMM2 phosphomannomutase 2
PPIB peptidylprolyl isomerase B (cyclophilin B)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS8 protease, serine, 8
RAB38 RAB38, member RAS oncogene family
RNASE6 ribonuclease, RNase A family, k6
SAT1 spermidine/spermine N1-acetyltransferase 1
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SOCS1 suppressor of cytokine signaling 1
STAR steroidogenic acute regulatory protein
TARP TCR gamma alternate reading frame protein
TGFA transforming growth factor, alpha
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRAPPC6A trafficking protein particle complex 6A
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB3 tribbles pseudokinase 3
ZFPM2 zinc finger protein, FOG family member 2
ZNF274 zinc finger protein 274

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
AK1 adenylate kinase 1
AK4 adenylate kinase 4
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BZW1 basic leucine zipper and W2 domains 1
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDC42 cell division cycle 42
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL14A1 collagen, type XIV, alpha 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
EDNRB endothelin receptor type B
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM107A family with sequence similarity 107, member A
FAM46A family with sequence similarity 46, member A
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
HPRT1 hypoxanthine phosphoribosyltransferase 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KLK11 kallikrein-related peptidase 11
LMCD1 LIM and cysteine-rich domains 1
MRPS16 mitochondrial ribosomal protein S16
PCDH9 protocadherin 9
PLS3 plastin 3
PRSS3 protease, serine, 3
RCAN1 regulator of calcineurin 1
RHOBTB3 Rho-related BTB domain containing 3
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
SC5D sterol-C5-desaturase
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SNX7 sorting nexin 7
SPINK1 serine peptidase inhibitor, Kazal type 1
TFF3 trefoil factor 3 (intestinal)
THY1 Thy-1 cell surface antigen
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
UPP1 uridine phosphorylase 1
VCL vinculin
ZCCHC24 zinc finger, CCHC domain containing 24