BRD-A10188456_DEXAMETHASONE_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

127 genes differentially expressed following the BRD-A10188456_DEXAMETHASONE_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
ADAMDEC1 ADAM-like, decysin 1
AHNAK AHNAK nucleoprotein
ALOX15B arachidonate 15-lipoxygenase, type B
ANPEP alanyl (membrane) aminopeptidase
APOA1 apolipoprotein A-I
APOC1 apolipoprotein C-I
BAX BCL2-associated X protein
C10ORF10 chromosome 10 open reading frame 10
CA2 carbonic anhydrase II
CCND2 cyclin D2
CD40 CD40 molecule, TNF receptor superfamily member 5
CD47 CD47 molecule
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CES2 carboxylesterase 2
CLCA1 chloride channel accessory 1
CTSZ cathepsin Z
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DPP4 dipeptidyl-peptidase 4
DUSP1 dual specificity phosphatase 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAIM Fas apoptotic inhibitory molecule
FCGBP Fc fragment of IgG binding protein
FHL1 four and a half LIM domains 1
FKBP5 FK506 binding protein 5
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GLUL glutamate-ammonia ligase
HIST1H2BG histone cluster 1, H2bg
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LDOC1 leucine zipper, down-regulated in cancer 1
LYZ lysozyme
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MME membrane metallo-endopeptidase
MT1E metallothionein 1E
MT1H metallothionein 1H
MT1M metallothionein 1M
NCAM1 neural cell adhesion molecule 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NPTX2 neuronal pentraxin II
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDZK1IP1 PDZK1 interacting protein 1
RASSF4 Ras association (RalGDS/AF-6) domain family member 4
REG1A regenerating islet-derived 1 alpha
REG1B regenerating islet-derived 1 beta
REG3A regenerating islet-derived 3 alpha
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
S100A8 S100 calcium binding protein A8
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SI sucrase-isomaltase (alpha-glucosidase)
SIK1 salt-inducible kinase 1
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINK4 serine peptidase inhibitor, Kazal type 4
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRGN serglycin
TMSB15B thymosin beta 15B
TRAPPC4 trafficking protein particle complex 4
TSC22D3 TSC22 domain family, member 3
VAMP8 vesicle-associated membrane protein 8
VCAN versican
ZBTB16 zinc finger and BTB domain containing 16
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
AK1 adenylate kinase 1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANO1 anoctamin 1, calcium activated chloride channel
ARHGAP29 Rho GTPase activating protein 29
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CAPN3 calpain 3, (p94)
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CEMIP cell migration inducing protein, hyaluronan binding
CHPT1 choline phosphotransferase 1
CLEC2B C-type lectin domain family 2, member B
CXCL8 chemokine (C-X-C motif) ligand 8
DCBLD2 discoidin, CUB and LCCL domain containing 2
DLC1 DLC1 Rho GTPase activating protein
DUSP4 dual specificity phosphatase 4
ETV1 ets variant 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
GPRC5B G protein-coupled receptor, class C, group 5, member B
GSTM3 glutathione S-transferase mu 3 (brain)
HOMER1 homer scaffolding protein 1
IER3 immediate early response 3
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
IGHD immunoglobulin heavy constant delta
LBH limb bud and heart development
LIF leukemia inhibitory factor
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MB myoglobin
MBP myelin basic protein
MID1 midline 1
MMD monocyte to macrophage differentiation-associated
NAV3 neuron navigator 3
NPTX1 neuronal pentraxin I
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRN1 neuritin 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLS3 plastin 3
POSTN periostin, osteoblast specific factor
PRNP prion protein
RNF144A ring finger protein 144A
SFRP4 secreted frizzled-related protein 4
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMAD3 SMAD family member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
TMEM97 transmembrane protein 97
WSB2 WD repeat and SOCS box containing 2
WT1 Wilms tumor 1