BRD-A10188456_DEXAMETHASONE_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

199 genes differentially expressed following the BRD-A10188456_DEXAMETHASONE_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AREG amphiregulin
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASS1 argininosuccinate synthase 1
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP11B ATPase, class VI, type 11B
BIRC3 baculoviral IAP repeat containing 3
BTG2 BTG family, member 2
C5AR1 complement component 5a receptor 1
CA2 carbonic anhydrase II
CCL20 chemokine (C-C motif) ligand 20
CCND2 cyclin D2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFB complement factor B
CFLAR CASP8 and FADD-like apoptosis regulator
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CSTA cystatin A (stefin A)
CTSD cathepsin D
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CYB5A cytochrome b5 type A (microsomal)
DDIT4 DNA-damage-inducible transcript 4
DMBT1 deleted in malignant brain tumors 1
DUSP1 dual specificity phosphatase 1
EHF ets homologous factor
FAM134B family with sequence similarity 134, member B
FHL1 four and a half LIM domains 1
FKBP5 FK506 binding protein 5
FPR1 formyl peptide receptor 1
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GLUL glutamate-ammonia ligase
HACD1 3-hydroxyacyl-CoA dehydratase 1
HBB hemoglobin, beta
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGHM immunoglobulin heavy constant mu
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JUP junction plakoglobin
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
LTF lactotransferrin
MAOA monoamine oxidase A
MME membrane metallo-endopeptidase
MPO myeloperoxidase
MUC1 mucin 1, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PDLIM1 PDZ and LIM domain 1
PDZK1IP1 PDZK1 interacting protein 1
PER1 period circadian clock 1
PGC progastricsin (pepsinogen C)
PKP2 plakophilin 2
PLBD1 phospholipase B domain containing 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PRR15L proline rich 15-like
RAB25 RAB25, member RAS oncogene family
RAB4A RAB4A, member RAS oncogene family
RHOB ras homolog family member B
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFTPB surfactant protein B
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SOD2 superoxide dismutase 2, mitochondrial
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
STK26 serine/threonine protein kinase 26
TBXA2R thromboxane A2 receptor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIP1 TNFAIP3 interacting protein 1
TOB1 transducer of ERBB2, 1
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
TYMP thymidine phosphorylase
ZBTB16 zinc finger and BTB domain containing 16
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA1 annexin A1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARL4C ADP-ribosylation factor-like 4C
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AXL AXL receptor tyrosine kinase
BAMBI BMP and activin membrane-bound inhibitor
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CADM1 cell adhesion molecule 1
CAST calpastatin
CCL2 chemokine (C-C motif) ligand 2
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CLEC2B C-type lectin domain family 2, member B
COL15A1 collagen, type XV, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL5A1 collagen, type V, alpha 1
COLEC12 collectin sub-family member 12
CSRP1 cysteine and glycine-rich protein 1
CYR61 cysteine-rich, angiogenic inducer, 61
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNM1 dynamin 1
DST dystonin
EPHB2 EPH receptor B2
ETV5 ets variant 5
FADS1 fatty acid desaturase 1
FBN1 fibrillin 1
FHL2 four and a half LIM domains 2
FLRT2 fibronectin leucine rich transmembrane protein 2
FOSL1 FOS-like antigen 1
GAP43 growth associated protein 43
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLIPR1 GLI pathogenesis-related 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GOLGA8H golgin A8 family, member H
HES1 hes family bHLH transcription factor 1
HJURP Holliday junction recognition protein
HOXB2 homeobox B2
IER3 immediate early response 3
KIF2C kinesin family member 2C
KRT15 keratin 15, type I
LAMA4 laminin, alpha 4
LGALS1 lectin, galactoside-binding, soluble, 1
LMO2 LIM domain only 2 (rhombotin-like 1)
LYPD1 LY6/PLAUR domain containing 1
MACF1 microtubule-actin crosslinking factor 1
MAP1B microtubule-associated protein 1B
MARCKS myristoylated alanine-rich protein kinase C substrate
MATN2 matrilin 2
MDFIC MyoD family inhibitor domain containing
MDK midkine (neurite growth-promoting factor 2)
MGLL monoglyceride lipase
MID1 midline 1
MKI67 marker of proliferation Ki-67
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NDRG4 NDRG family member 4
NPAS2 neuronal PAS domain protein 2
NPY1R neuropeptide Y receptor Y1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NTS neurotensin
NUDCD3 NudC domain containing 3
PALLD palladin, cytoskeletal associated protein
PBX1 pre-B-cell leukemia homeobox 1
PBX3 pre-B-cell leukemia homeobox 3
PDGFA platelet-derived growth factor alpha polypeptide
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLK1 polo-like kinase 1
PLXNC1 plexin C1
PMEPA1 prostate transmembrane protein, androgen induced 1
PMP22 peripheral myelin protein 22
PSRC1 proline/serine-rich coiled-coil 1
PTN pleiotrophin
RBP1 retinol binding protein 1, cellular
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RND3 Rho family GTPase 3
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SMC1A structural maintenance of chromosomes 1A
SOX9 SRY (sex determining region Y)-box 9
SPDEF SAM pointed domain containing ETS transcription factor
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SQSTM1 sequestosome 1
SYNJ2 synaptojanin 2
TBX3 T-box 3
TCF4 transcription factor 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF3 trefoil factor 3 (intestinal)
TGFBI transforming growth factor, beta-induced, 68kDa
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TUBB2B tubulin, beta 2B class IIb
TUBB3 tubulin, beta 3 class III
TUBB6 tubulin, beta 6 class V
WNT5A wingless-type MMTV integration site family, member 5A
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZCCHC24 zinc finger, CCHC domain containing 24