BRD-A10188456_-666_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

155 genes differentially expressed following the BRD-A10188456_-666_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
AHNAK AHNAK nucleoprotein
AHNAK2 AHNAK nucleoprotein 2
AKAP13 A kinase (PRKA) anchor protein 13
ANPEP alanyl (membrane) aminopeptidase
ASPN asporin
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL6 B-cell CLL/lymphoma 6
BGN biglycan
C10ORF10 chromosome 10 open reading frame 10
C3 complement component 3
C5AR1 complement component 5a receptor 1
CALD1 caldesmon 1
CAV2 caveolin 2
CD163 CD163 molecule
CD59 CD59 molecule, complement regulatory protein
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK19 cyclin-dependent kinase 19
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CP ceruloplasmin (ferroxidase)
CPM carboxypeptidase M
CSTA cystatin A (stefin A)
CTGF connective tissue growth factor
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
FERMT2 fermitin family member 2
FGFR2 fibroblast growth factor receptor 2
FKBP5 FK506 binding protein 5
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GLRX glutaredoxin (thioltransferase)
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
KLF7 Kruppel-like factor 7 (ubiquitous)
KLF9 Kruppel-like factor 9
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LPL lipoprotein lipase
MAOB monoamine oxidase B
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MPZL2 myelin protein zero-like 2
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MT1E metallothionein 1E
MT1M metallothionein 1M
MT1X metallothionein 1X
NCF2 neutrophil cytosolic factor 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NOX4 NADPH oxidase 4
OSBPL10 oxysterol binding protein-like 10
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDZD2 PDZ domain containing 2
PER1 period circadian clock 1
PICALM phosphatidylinositol binding clathrin assembly protein
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PRKCD protein kinase C, delta
PTPRF protein tyrosine phosphatase, receptor type, F
PTPRO protein tyrosine phosphatase, receptor type, O
PXN paxillin
S100A8 S100 calcium binding protein A8
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC38A2 solute carrier family 38, member 2
SOX11 SRY (sex determining region Y)-box 11
SULF1 sulfatase 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TIMP3 TIMP metallopeptidase inhibitor 3
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TMEM204 transmembrane protein 204
TREM1 triggering receptor expressed on myeloid cells 1
TSC22D3 TSC22 domain family, member 3
VCAN versican
VSIG4 V-set and immunoglobulin domain containing 4
ZBTB16 zinc finger and BTB domain containing 16
ZFP36 ZFP36 ring finger protein
ZNF512B zinc finger protein 512B
ZW10 zw10 kinetochore protein

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
AGR2 anterior gradient 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AURKA aurora kinase A
BIN1 bridging integrator 1
C2CD2 C2 calcium-dependent domain containing 2
CCL2 chemokine (C-C motif) ligand 2
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COCH cochlin
CST1 cystatin SN
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL8 chemokine (C-X-C motif) ligand 8
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DEFB1 defensin, beta 1
DUSP4 dual specificity phosphatase 4
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ETV5 ets variant 5
FERMT1 fermitin family member 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GDF15 growth differentiation factor 15
GOLM1 golgi membrane protein 1
GPX2 glutathione peroxidase 2
GSTM3 glutathione S-transferase mu 3 (brain)
GSTP1 glutathione S-transferase pi 1
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HOMER1 homer scaffolding protein 1
HSPA8 heat shock 70kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI6 interferon, alpha-inducible protein 6
IGFBP3 insulin-like growth factor binding protein 3
LAPTM4B lysosomal protein transmembrane 4 beta
LCN2 lipocalin 2
LY6D lymphocyte antigen 6 complex, locus D
MARCKS myristoylated alanine-rich protein kinase C substrate
MATN2 matrilin 2
MID1 midline 1
NAV3 neuron navigator 3
NQO1 NAD(P)H dehydrogenase, quinone 1
NR0B1 nuclear receptor subfamily 0, group B, member 1
NTS neurotensin
OLFML3 olfactomedin-like 3
PCP4 Purkinje cell protein 4
PFDN4 prefoldin subunit 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK2 polo-like kinase 2
PPIF peptidylprolyl isomerase F
QPRT quinolinate phosphoribosyltransferase
RAP1GAP RAP1 GTPase activating protein
RCN1 reticulocalbin 1, EF-hand calcium binding domain
SCGB2A1 secretoglobin, family 2A, member 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SPRY2 sprouty homolog 2 (Drosophila)
TBC1D4 TBC1 domain family, member 4
TESC tescalcin
TFF3 trefoil factor 3 (intestinal)
TNNT1 troponin T type 1 (skeletal, slow)
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)