BRD-A09984573_CD 01333_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-A09984573_CD 01333_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALOX5 arachidonate 5-lipoxygenase
ANGPTL2 angiopoietin-like 2
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
CD163 CD163 molecule
CES1 carboxylesterase 1
CHI3L2 chitinase 3-like 2
CLIP3 CAP-GLY domain containing linker protein 3
COLEC12 collectin sub-family member 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDR2 discoidin domain receptor tyrosine kinase 2
DENND1B DENN/MADD domain containing 1B
DUOX2 dual oxidase 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAS Fas cell surface death receptor
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GAP43 growth associated protein 43
GBP2 guanylate binding protein 2, interferon-inducible
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GPX2 glutathione peroxidase 2
HIRA histone cell cycle regulator
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
KAZN kazrin, periplakin interacting protein
KYNU kynureninase
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAOA monoamine oxidase A
MAOB monoamine oxidase B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NPTX2 neuronal pentraxin II
NQO1 NAD(P)H dehydrogenase, quinone 1
NR0B1 nuclear receptor subfamily 0, group B, member 1
NRCAM neuronal cell adhesion molecule
OLFM1 olfactomedin 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PFN2 profilin 2
PGD phosphogluconate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PPAP2B phosphatidic acid phosphatase type 2B
RAP1GAP RAP1 GTPase activating protein
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERTAD2 SERTA domain containing 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
SYNM synemin, intermediate filament protein
TALDO1 transaldolase 1
TDP2 tyrosyl-DNA phosphodiesterase 2
TKT transketolase
TRIB3 tribbles pseudokinase 3
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VEGFA vascular endothelial growth factor A
VWF von Willebrand factor
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
ATOX1 antioxidant 1 copper chaperone
BCHE butyrylcholinesterase
BIK BCL2-interacting killer (apoptosis-inducing)
C3ORF14 chromosome 3 open reading frame 14
DEPTOR DEP domain containing MTOR-interacting protein
EIF5A eukaryotic translation initiation factor 5A
ESR1 estrogen receptor 1
GPNMB glycoprotein (transmembrane) nmb
GSTZ1 glutathione S-transferase zeta 1
HES1 hes family bHLH transcription factor 1
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
KIAA0101 KIAA0101
KRT7 keratin 7, type II
LUM lumican
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
OAT ornithine aminotransferase
POSTN periostin, osteoblast specific factor
QDPR quinoid dihydropteridine reductase
RAB25 RAB25, member RAS oncogene family
RGS4 regulator of G-protein signaling 4
SH3BGRL SH3 domain binding glutamate-rich protein like
SLIRP SRA stem-loop interacting RNA binding protein
SPINT2 serine peptidase inhibitor, Kunitz type, 2
TFRC transferrin receptor
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS3 tensin 3