BRD-A09828896_SKF 81297 hydrobromide_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

162 genes differentially expressed following the BRD-A09828896_SKF 81297 hydrobromide_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG6 adhesion G protein-coupled receptor G6
ADGRL2 adhesion G protein-coupled receptor L2
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA9 annexin A9
ARMCX1 armadillo repeat containing, X-linked 1
ASS1 argininosuccinate synthase 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BMP4 bone morphogenetic protein 4
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD200 CD200 molecule
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDK14 cyclin-dependent kinase 14
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CRELD2 cysteine-rich with EGF-like domains 2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CXCR4 chemokine (C-X-C motif) receptor 4
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DENND1B DENN/MADD domain containing 1B
DEPTOR DEP domain containing MTOR-interacting protein
DES desmin
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOK5 docking protein 5
EDN1 endothelin 1
ERBB4 erb-b2 receptor tyrosine kinase 4
EXT1 exostosin glycosyltransferase 1
FAM129A family with sequence similarity 129, member A
FAM69A family with sequence similarity 69, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHOD3 formin homology 2 domain containing 3
FILIP1L filamin A interacting protein 1-like
FN1 fibronectin 1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GATA6 GATA binding protein 6
GMPR guanosine monophosphate reductase
GULP1 GULP, engulfment adaptor PTB domain containing 1
GYPC glycophorin C (Gerbich blood group)
H2AFY H2A histone family, member Y
HBB hemoglobin, beta
HDAC9 histone deacetylase 9
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGFBP7 insulin-like growth factor binding protein 7
IGLL1 immunoglobulin lambda-like polypeptide 1
ISYNA1 inositol-3-phosphate synthase 1
ITFG1 integrin alpha FG-GAP repeat containing 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KRT23 keratin 23, type I
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LRMP lymphoid-restricted membrane protein
MEIS2 Meis homeobox 2
MFAP5 microfibrillar associated protein 5
MYRF myelin regulatory factor
NLRP2 NLR family, pyrin domain containing 2
NT5E 5'-nucleotidase, ecto (CD73)
NVL nuclear VCP-like
NXN nucleoredoxin
OSBPL10 oxysterol binding protein-like 10
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRR15L proline rich 15-like
PRUNE2 prune homolog 2 (Drosophila)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRK protein tyrosine phosphatase, receptor type, K
PYCARD PYD and CARD domain containing
RAI14 retinoic acid induced 14
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RTN1 reticulon 1
RTN2 reticulon 2
S100A8 S100 calcium binding protein A8
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SHB Src homology 2 domain containing adaptor protein B
SOX17 SRY (sex determining region Y)-box 17
SRGN serglycin
STS steroid sulfatase (microsomal), isozyme S
STX3 syntaxin 3
TMEM35 transmembrane protein 35
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TRIB3 tribbles pseudokinase 3
TUSC3 tumor suppressor candidate 3
UBE2J1 ubiquitin-conjugating enzyme E2, J1
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VGLL1 vestigial-like family member 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC1 WAP four-disulfide core domain 1
WNT5B wingless-type MMTV integration site family, member 5B
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANXA5 annexin A5
APLP2 amyloid beta (A4) precursor-like protein 2
BAG2 BCL2-associated athanogene 2
BAZ1A bromodomain adjacent to zinc finger domain, 1A
C1S complement component 1, s subcomponent
CA12 carbonic anhydrase XII
CBR3 carbonyl reductase 3
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD81 CD81 molecule
CDC123 cell division cycle 123
CRIP1 cysteine-rich protein 1 (intestinal)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CTTN cortactin
EIF5A eukaryotic translation initiation factor 5A
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
F13A1 coagulation factor XIII, A1 polypeptide
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FKBP5 FK506 binding protein 5
G0S2 G0/G1 switch 2
GLUL glutamate-ammonia ligase
GPX3 glutathione peroxidase 3
GRB14 growth factor receptor-bound protein 14
GSTA4 glutathione S-transferase alpha 4
H1F0 H1 histone family, member 0
HES1 hes family bHLH transcription factor 1
HLTF helicase-like transcription factor
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
IGF1R insulin-like growth factor 1 receptor
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MCOLN1 mucolipin 1
MET MET proto-oncogene, receptor tyrosine kinase
MRPS30 mitochondrial ribosomal protein S30
NFIB nuclear factor I/B
NUP85 nucleoporin 85kDa
PCDH9 protocadherin 9
PFKP phosphofructokinase, platelet
PI3 peptidase inhibitor 3, skin-derived
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PTMA prothymosin, alpha
RAD51C RAD51 paralog C
RPL37A ribosomal protein L37a
S100A10 S100 calcium binding protein A10
S100A2 S100 calcium binding protein A2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SET SET nuclear proto-oncogene
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
TFF3 trefoil factor 3 (intestinal)
TSPAN8 tetraspanin 8
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
VAV3 vav 3 guanine nucleotide exchange factor
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta