BRD-A09828896_-666_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-A09828896_-666_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BEX4 brain expressed, X-linked 4
CA11 carbonic anhydrase XI
CAST calpastatin
CBS cystathionine-beta-synthase
CCK cholecystokinin
CCL4 chemokine (C-C motif) ligand 4
CD9 CD9 molecule
CDK14 cyclin-dependent kinase 14
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CLC Charcot-Leyden crystal galectin
COL6A3 collagen, type VI, alpha 3
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSTA cystatin A (stefin A)
DDIT4 DNA-damage-inducible transcript 4
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
EDNRA endothelin receptor type A
ERAP1 endoplasmic reticulum aminopeptidase 1
FCGBP Fc fragment of IgG binding protein
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GPC3 glypican 3
GRB7 growth factor receptor-bound protein 7
HBB hemoglobin, beta
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HSPA4 heat shock 70kDa protein 4
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFRD2 interferon-related developmental regulator 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGL immunoglobulin lambda locus
ISG20 interferon stimulated exonuclease gene 20kDa
LIMCH1 LIM and calponin homology domains 1
MEF2C myocyte enhancer factor 2C
MMP1 matrix metallopeptidase 1
MSLN mesothelin
NCAM1 neural cell adhesion molecule 1
NEFL neurofilament, light polypeptide
NELL2 NEL-like 2 (chicken)
NGRN neugrin, neurite outgrowth associated
NMU neuromedin U
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
OSBPL10 oxysterol binding protein-like 10
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCLO piccolo presynaptic cytomatrix protein
PHGDH phosphoglycerate dehydrogenase
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PPOX protoporphyrinogen oxidase
RGCC regulator of cell cycle
RNASE6 ribonuclease, RNase A family, k6
S100A8 S100 calcium binding protein A8
SARS seryl-tRNA synthetase
SCPEP1 serine carboxypeptidase 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC38A1 solute carrier family 38, member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SOX11 SRY (sex determining region Y)-box 11
TMSB15A thymosin beta 15a
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AGR2 anterior gradient 2
AMACR alpha-methylacyl-CoA racemase
ASRGL1 asparaginase like 1
BAG2 BCL2-associated athanogene 2
C2CD2 C2 calcium-dependent domain containing 2
CLDN1 claudin 1
CLU clusterin
COBL cordon-bleu WH2 repeat protein
CRIP1 cysteine-rich protein 1 (intestinal)
CSRP1 cysteine and glycine-rich protein 1
CXCL5 chemokine (C-X-C motif) ligand 5
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GPM6B glycoprotein M6B
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KLK11 kallikrein-related peptidase 11
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAPTM4B lysosomal protein transmembrane 4 beta
LSP1 lymphocyte-specific protein 1
MAP7 microtubule-associated protein 7
MGST2 microsomal glutathione S-transferase 2
MSX1 msh homeobox 1
PEBP1 phosphatidylethanolamine binding protein 1
PLAC8 placenta-specific 8
QDPR quinoid dihydropteridine reductase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAI14 retinoic acid induced 14
RGS2 regulator of G-protein signaling 2
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
SFN stratifin
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SNRPE small nuclear ribonucleoprotein polypeptide E
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
TARP TCR gamma alternate reading frame protein
TESC tescalcin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TPSB2 tryptase beta 2 (gene/pseudogene)
USP48 ubiquitin specific peptidase 48
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon