BRD-A09719808_NCGC00188536-01_HT29_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

125 genes differentially expressed following the BRD-A09719808_NCGC00188536-01_HT29_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
BST2 bone marrow stromal cell antigen 2
CCND2 cyclin D2
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEMIP cell migration inducing protein, hyaluronan binding
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
COL4A6 collagen, type IV, alpha 6
CTSL cathepsin L
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EPAS1 endothelial PAS domain protein 1
EREG epiregulin
FAS Fas cell surface death receptor
FKBP11 FK506 binding protein 11, 19 kDa
GBP1 guanylate binding protein 1, interferon-inducible
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GPX2 glutathione peroxidase 2
HCP5 HLA complex P5 (non-protein coding)
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
IFI16 interferon, gamma-inducible protein 16
IFI27 interferon, alpha-inducible protein 27
IFI35 interferon-induced protein 35
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIH1 interferon induced with helicase C domain 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
IFITM1 interferon induced transmembrane protein 1
IGL immunoglobulin lambda locus
IRF7 interferon regulatory factor 7
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
LAMP3 lysosomal-associated membrane protein 3
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
NAMPT nicotinamide phosphoribosyltransferase
NEFL neurofilament, light polypeptide
NMI N-myc (and STAT) interactor
NT5E 5'-nucleotidase, ecto (CD73)
NUCB2 nucleobindin 2
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OASL 2'-5'-oligoadenylate synthetase-like
ODC1 ornithine decarboxylase 1
PARP12 poly (ADP-ribose) polymerase family, member 12
PHF11 PHD finger protein 11
PLSCR1 phospholipid scramblase 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
RNASET2 ribonuclease T2
RSAD2 radical S-adenosyl methionine domain containing 2
RTP4 receptor (chemosensory) transporter protein 4
SAMD9 sterile alpha motif domain containing 9
SCML1 sex comb on midleg-like 1 (Drosophila)
SMAD3 SMAD family member 3
SOCS2 suppressor of cytokine signaling 2
SP100 SP100 nuclear antigen
SP110 SP110 nuclear body protein
STAT1 signal transducer and activator of transcription 1, 91kDa
STC2 stanniocalcin 2
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TRIM22 tripartite motif containing 22
UBE2L6 ubiquitin-conjugating enzyme E2L 6
USP18 ubiquitin specific peptidase 18
WARS tryptophanyl-tRNA synthetase
XAF1 XIAP associated factor 1

decreased expression

Symbol Name
AAMDC adipogenesis associated, Mth938 domain containing
ASCL1 achaete-scute family bHLH transcription factor 1
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BGN biglycan
C8ORF4 chromosome 8 open reading frame 4
CASP7 caspase 7, apoptosis-related cysteine peptidase
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CRIP1 cysteine-rich protein 1 (intestinal)
CRIP2 cysteine-rich protein 2
EFNB2 ephrin-B2
GATA2 GATA binding protein 2
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HMGN3 high mobility group nucleosomal binding domain 3
HP haptoglobin
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
LOXL1 lysyl oxidase-like 1
LTF lactotransferrin
MED21 mediator complex subunit 21
MTA1 metastasis associated 1
NREP neuronal regeneration related protein
OXTR oxytocin receptor
PIP prolactin-induced protein
PROM1 prominin 1
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SCYL3 SCY1-like 3 (S. cerevisiae)
TAGLN2 transgelin 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TMSB15A thymosin beta 15a