BRD-A09719808_NCGC00188536-01_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

145 genes differentially expressed following the BRD-A09719808_NCGC00188536-01_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASPN asporin
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BGN biglycan
BTG2 BTG family, member 2
CADM1 cell adhesion molecule 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CEMIP cell migration inducing protein, hyaluronan binding
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
CSRP1 cysteine and glycine-rich protein 1
CTSE cathepsin E
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
DCN decorin
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSG3 desmoglein 3
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR2 early growth response 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAS GNAS complex locus
GRWD1 glutamate-rich WD repeat containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
INHBA inhibin, beta A
ISG20 interferon stimulated exonuclease gene 20kDa
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KRT6A keratin 6A, type II
LIMCH1 LIM and calponin homology domains 1
MFAP2 microfibrillar-associated protein 2
MFAP5 microfibrillar associated protein 5
MMP1 matrix metallopeptidase 1
MSLN mesothelin
MTUS1 microtubule associated tumor suppressor 1
NDNF neuron-derived neurotrophic factor
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
ODC1 ornithine decarboxylase 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PON3 paraoxonase 3
POSTN periostin, osteoblast specific factor
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SFTPD surfactant protein D
SGK1 serum/glucocorticoid regulated kinase 1
SLC31A2 solute carrier family 31 (copper transporter), member 2
SULF1 sulfatase 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
THBS2 thrombospondin 2
TMEM176B transmembrane protein 176B
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB1 tribbles pseudokinase 1
TRIM2 tripartite motif containing 2
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADRB2 adrenoceptor beta 2, surface
ALOX5 arachidonate 5-lipoxygenase
ASRGL1 asparaginase like 1
C7 complement component 7
CAV2 caveolin 2
CD24 CD24 molecule
CDC42 cell division cycle 42
CLU clusterin
COL4A1 collagen, type IV, alpha 1
CP ceruloplasmin (ferroxidase)
CPNE3 copine III
CRABP2 cellular retinoic acid binding protein 2
CRIP2 cysteine-rich protein 2
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DCK deoxycytidine kinase
DEFB1 defensin, beta 1
DUSP3 dual specificity phosphatase 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFR epidermal growth factor receptor
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FBXO21 F-box protein 21
FOLR1 folate receptor 1 (adult)
G0S2 G0/G1 switch 2
GPX1 glutathione peroxidase 1
GPX3 glutathione peroxidase 3
GRN granulin
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
KANK1 KN motif and ankyrin repeat domains 1
LCN2 lipocalin 2
LITAF lipopolysaccharide-induced TNF factor
MMD monocyte to macrophage differentiation-associated
MTA1 metastasis associated 1
NFIB nuclear factor I/B
PFKP phosphofructokinase, platelet
PPAT phosphoribosyl pyrophosphate amidotransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBP1 retinol binding protein 1, cellular
RPL39L ribosomal protein L39-like
RRP1B ribosomal RNA processing 1B
S100A9 S100 calcium binding protein A9
SET SET nuclear proto-oncogene
TCTN1 tectonic family member 1
TMSB15A thymosin beta 15a
TTC3 tetratricopeptide repeat domain 3
UBE2G2 ubiquitin-conjugating enzyme E2G 2
USP46 ubiquitin specific peptidase 46
ZMAT3 zinc finger, matrin-type 3