BRD-A09719808_NCGC00188536-01_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

255 genes differentially expressed following the BRD-A09719808_NCGC00188536-01_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
AMOTL2 angiomotin like 2
APOD apolipoprotein D
ARMCX1 armadillo repeat containing, X-linked 1
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
C10ORF10 chromosome 10 open reading frame 10
CA2 carbonic anhydrase II
CAV1 caveolin 1, caveolae protein, 22kDa
CCL4 chemokine (C-C motif) ligand 4
CD40 CD40 molecule, TNF receptor superfamily member 5
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN3 claudin 3
CNN3 calponin 3, acidic
COL2A1 collagen, type II, alpha 1
CPE carboxypeptidase E
CPM carboxypeptidase M
CRABP1 cellular retinoic acid binding protein 1
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTGF connective tissue growth factor
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EDN1 endothelin 1
EFHD1 EF-hand domain family, member D1
EGR1 early growth response 1
EPAS1 endothelial PAS domain protein 1
FBXL12 F-box and leucine-rich repeat protein 12
FGFR2 fibroblast growth factor receptor 2
FILIP1L filamin A interacting protein 1-like
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FRZB frizzled-related protein
FXYD6 FXYD domain containing ion transport regulator 6
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GJA1 gap junction protein, alpha 1, 43kDa
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GRB7 growth factor receptor-bound protein 7
H2BFS H2B histone family, member S (pseudogene)
H3F3B H3 histone, family 3B (H3.3B)
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BI histone cluster 1, H2bi
HIST1H2BK histone cluster 1, H2bk
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IRF8 interferon regulatory factor 8
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCTD12 potassium channel tetramerization domain containing 12
KLF10 Kruppel-like factor 10
KLF11 Kruppel-like factor 11
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT15 keratin 15, type I
KRT23 keratin 23, type I
LAPTM5 lysosomal protein transmembrane 5
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MEIS2 Meis homeobox 2
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEK3 NIMA-related kinase 3
NGRN neugrin, neurite outgrowth associated
NLRP2 NLR family, pyrin domain containing 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
ODC1 ornithine decarboxylase 1
OSR2 odd-skipped related transciption factor 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDE4B phosphodiesterase 4B, cAMP-specific
PELI1 pellino E3 ubiquitin protein ligase 1
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPRC protein tyrosine phosphatase, receptor type, C
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RRM2 ribonucleotide reductase M2
RTN2 reticulon 2
SDC1 syndecan 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SIK1 salt-inducible kinase 1
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SNAI2 snail family zinc finger 2
SOCS2 suppressor of cytokine signaling 2
SOX9 SRY (sex determining region Y)-box 9
SPON1 spondin 1, extracellular matrix protein
SRGN serglycin
STC1 stanniocalcin 1
TFPI2 tissue factor pathway inhibitor 2
TFRC transferrin receptor
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMSB15A thymosin beta 15a
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPM1 tropomyosin 1 (alpha)
TSPAN7 tetraspanin 7
TYROBP TYRO protein tyrosine kinase binding protein
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF532 zinc finger protein 532

decreased expression

Symbol Name
AARS alanyl-tRNA synthetase
ABHD2 abhydrolase domain containing 2
ACSL1 acyl-CoA synthetase long-chain family member 1
ADD3 adducin 3 (gamma)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDOC aldolase C, fructose-bisphosphate
AMDHD2 amidohydrolase domain containing 2
ANGPT1 angiopoietin 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASPH aspartate beta-hydroxylase
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
B3GNT1
BCR breakpoint cluster region
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BST2 bone marrow stromal cell antigen 2
BTN3A2 butyrophilin, subfamily 3, member A2
C3 complement component 3
CCDC85B coiled-coil domain containing 85B
CD59 CD59 molecule, complement regulatory protein
CDC25B cell division cycle 25B
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CFI complement factor I
CHPT1 choline phosphotransferase 1
CKAP4 cytoskeleton-associated protein 4
CLCN3 chloride channel, voltage-sensitive 3
CLTC clathrin, heavy chain (Hc)
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
CPD carboxypeptidase D
CPNE3 copine III
CTSB cathepsin B
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYFIP2 cytoplasmic FMR1 interacting protein 2
DCXR dicarbonyl/L-xylulose reductase
ECI2 enoyl-CoA delta isomerase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ETFB electron-transfer-flavoprotein, beta polypeptide
FADS1 fatty acid desaturase 1
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GAS7 growth arrest-specific 7
GDE1 glycerophosphodiester phosphodiesterase 1
GSTT1 glutathione S-transferase theta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HOXC6 homeobox C6
HSDL2 hydroxysteroid dehydrogenase like 2
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IL6ST interleukin 6 signal transducer
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KDM5B lysine (K)-specific demethylase 5B
KIAA1033 KIAA1033
KIF1B kinesin family member 1B
KLHL9 kelch-like family member 9
KYNU kynureninase
LAMC1 laminin, gamma 1 (formerly LAMB2)
LEF1 lymphoid enhancer-binding factor 1
LPGAT1 lysophosphatidylglycerol acyltransferase 1
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
MAGED1 melanoma antigen family D1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGP matrix Gla protein
MLF1 myeloid leukemia factor 1
MSRB2 methionine sulfoxide reductase B2
MVP major vault protein
MYH10 myosin, heavy chain 10, non-muscle
NEK7 NIMA-related kinase 7
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NISCH nischarin
NNMT nicotinamide N-methyltransferase
NPC2 Niemann-Pick disease, type C2
NQO1 NAD(P)H dehydrogenase, quinone 1
NRIP1 nuclear receptor interacting protein 1
OAT ornithine aminotransferase
OSBPL8 oxysterol binding protein-like 8
PLAT plasminogen activator, tissue
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PRKCD protein kinase C, delta
PWP1 PWP1 homolog (S. cerevisiae)
QPCT glutaminyl-peptide cyclotransferase
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
SEC23A Sec23 homolog A (S. cerevisiae)
SERP1 stress-associated endoplasmic reticulum protein 1
SKAP2 src kinase associated phosphoprotein 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORD sorbitol dehydrogenase
SREBF1 sterol regulatory element binding transcription factor 1
SRPX sushi-repeat containing protein, X-linked
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SVIL supervillin
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBL1X transducin (beta)-like 1X-linked
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TLR4 toll-like receptor 4
TMX4 thioredoxin-related transmembrane protein 4
TOM1L1 target of myb1 (chicken)-like 1
TOP2B topoisomerase (DNA) II beta 180kDa
TPD52L1 tumor protein D52-like 1
TSPAN13 tetraspanin 13
TSPAN6 tetraspanin 6
TSTA3 tissue specific transplantation antigen P35B
TXNRD1 thioredoxin reductase 1
WNT5A wingless-type MMTV integration site family, member 5A
YME1L1 YME1-like 1 ATPase