BRD-A09539288_HOMATROPINE BROMIDE_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

133 genes differentially expressed following the BRD-A09539288_HOMATROPINE BROMIDE_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADRB2 adrenoceptor beta 2, surface
ALOX5 arachidonate 5-lipoxygenase
ATP11B ATPase, class VI, type 11B
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
AUTS2 autism susceptibility candidate 2
BNC2 basonuclin 2
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CALML4 calmodulin-like 4
CALR calreticulin
CCND2 cyclin D2
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CLDN3 claudin 3
COG7 component of oligomeric golgi complex 7
CRABP2 cellular retinoic acid binding protein 2
CSTA cystatin A (stefin A)
CTNND1 catenin (cadherin-associated protein), delta 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DENND1B DENN/MADD domain containing 1B
DMD dystrophin
DMXL2 Dmx-like 2
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EDNRA endothelin receptor type A
EGFL6 EGF-like-domain, multiple 6
EXT1 exostosin glycosyltransferase 1
FAM69A family with sequence similarity 69, member A
FASN fatty acid synthase
FHOD3 formin homology 2 domain containing 3
FLRT2 fibronectin leucine rich transmembrane protein 2
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HIST1H2BD histone cluster 1, H2bd
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGF2R insulin-like growth factor 2 receptor
IGHM immunoglobulin heavy constant mu
ITGA6 integrin, alpha 6
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
JAG1 jagged 1
KCTD12 potassium channel tetramerization domain containing 12
KDR kinase insert domain receptor
LAPTM5 lysosomal protein transmembrane 5
LPAR6 lysophosphatidic acid receptor 6
LYN LYN proto-oncogene, Src family tyrosine kinase
MAN1A1 mannosidase, alpha, class 1A, member 1
MEST mesoderm specific transcript
MYO1B myosin IB
NELL2 NEL-like 2 (chicken)
NISCH nischarin
NRP1 neuropilin 1
NTAN1 N-terminal asparagine amidase
NVL nuclear VCP-like
NXN nucleoredoxin
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PEG10 paternally expressed 10
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLXNA1 plexin A1
PLXNC1 plexin C1
PMM2 phosphomannomutase 2
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRK protein tyrosine phosphatase, receptor type, K
PXN paxillin
PYCARD PYD and CARD domain containing
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS1 regulator of G-protein signaling 1
SCPEP1 serine carboxypeptidase 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SHB Src homology 2 domain containing adaptor protein B
SPON2 spondin 2, extracellular matrix protein
STS steroid sulfatase (microsomal), isozyme S
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TCTA T-cell leukemia translocation altered
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
VNN1 vanin 1
XIST X inactive specific transcript (non-protein coding)
ZNF274 zinc finger protein 274

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
AGR2 anterior gradient 2
ANXA1 annexin A1
BAG2 BCL2-associated athanogene 2
BDH2 3-hydroxybutyrate dehydrogenase, type 2
CD59 CD59 molecule, complement regulatory protein
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN2A cyclin-dependent kinase inhibitor 2A
CHL1 cell adhesion molecule L1-like
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CST3 cystatin C
CXCL8 chemokine (C-X-C motif) ligand 8
DCK deoxycytidine kinase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
F3 coagulation factor III (thromboplastin, tissue factor)
FBXO9 F-box protein 9
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GPX3 glutathione peroxidase 3
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
KRT7 keratin 7, type II
MRPS30 mitochondrial ribosomal protein S30
MT1M metallothionein 1M
NNMT nicotinamide N-methyltransferase
PMP2 peripheral myelin protein 2
PON2 paraoxonase 2
PRDX2 peroxiredoxin 2
QDPR quinoid dihydropteridine reductase
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RCAN1 regulator of calcineurin 1
RPS11 ribosomal protein S11
SFN stratifin
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SST somatostatin
SUB1 SUB1 homolog (S. cerevisiae)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TOB1 transducer of ERBB2, 1
TSPAN13 tetraspanin 13