BRD-A09533288_VERAPAMIL HYDROCHLORIDE_RKO_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

149 genes differentially expressed following the BRD-A09533288_VERAPAMIL HYDROCHLORIDE_RKO_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
AIM1 absent in melanoma 1
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
APOD apolipoprotein D
AREG amphiregulin
ATP9A ATPase, class II, type 9A
BGN biglycan
BMP4 bone morphogenetic protein 4
C3ORF14 chromosome 3 open reading frame 14
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CEP57 centrosomal protein 57kDa
CHMP4A charged multivesicular body protein 4A
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL4A6 collagen, type IV, alpha 6
COL5A2 collagen, type V, alpha 2
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
EFHD1 EF-hand domain family, member D1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPAS1 endothelial PAS domain protein 1
F11R F11 receptor
FABP4 fatty acid binding protein 4, adipocyte
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FBP1 fructose-1,6-bisphosphatase 1
FBXO21 F-box protein 21
FHL1 four and a half LIM domains 1
FHOD3 formin homology 2 domain containing 3
FST follistatin
GPNMB glycoprotein (transmembrane) nmb
GPX2 glutathione peroxidase 2
HIST1H4C histone cluster 1, H4c
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HPRT1 hypoxanthine phosphoribosyltransferase 1
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
HSPA1A heat shock 70kDa protein 1A
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
IL1R1 interleukin 1 receptor, type I
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IPO13 importin 13
IQGAP1 IQ motif containing GTPase activating protein 1
IRF9 interferon regulatory factor 9
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KIAA1462 KIAA1462
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LPAR6 lysophosphatidic acid receptor 6
MAN1A1 mannosidase, alpha, class 1A, member 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP7 matrix metallopeptidase 7
MRPL13 mitochondrial ribosomal protein L13
NEBL nebulette
NID1 nidogen 1
PBX1 pre-B-cell leukemia homeobox 1
PCP4 Purkinje cell protein 4
PHACTR2 phosphatase and actin regulator 2
POLR1C polymerase (RNA) I polypeptide C, 30kDa
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
PPP1R13B protein phosphatase 1, regulatory subunit 13B
RAB20 RAB20, member RAS oncogene family
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RGS4 regulator of G-protein signaling 4
SDC2 syndecan 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SH3GL2 SH3-domain GRB2-like 2
SIRPA signal-regulatory protein alpha
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
SULF1 sulfatase 1
TBX3 T-box 3
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
TLR4 toll-like receptor 4
TNS3 tensin 3
VGLL1 vestigial-like family member 1
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
AMD1 adenosylmethionine decarboxylase 1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CASP2 caspase 2, apoptosis-related cysteine peptidase
CD47 CD47 molecule
CDC42 cell division cycle 42
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHL1 cell adhesion molecule L1-like
CLU clusterin
CXCL8 chemokine (C-X-C motif) ligand 8
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
ECI2 enoyl-CoA delta isomerase 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
EPN2 epsin 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FOLR1 folate receptor 1 (adult)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
IFITM2 interferon induced transmembrane protein 2
KDM5D lysine (K)-specific demethylase 5D
KRT10 keratin 10, type I
LBR lamin B receptor
MAP2K3 mitogen-activated protein kinase kinase 3
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MUC5B mucin 5B, oligomeric mucus/gel-forming
NAMPT nicotinamide phosphoribosyltransferase
NAV3 neuron navigator 3
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PI3 peptidase inhibitor 3, skin-derived
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PODXL podocalyxin-like
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
SACS sacsin molecular chaperone
SRSF6 serine/arginine-rich splicing factor 6
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TMOD1 tropomodulin 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TSPAN8 tetraspanin 8
UBE2S ubiquitin-conjugating enzyme E2S