BRD-A09533288_VERAPAMIL HYDROCHLORIDE_AGS_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

146 genes differentially expressed following the BRD-A09533288_VERAPAMIL HYDROCHLORIDE_AGS_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AIM1 absent in melanoma 1
ALDOB aldolase B, fructose-bisphosphate
AMIGO2 adhesion molecule with Ig-like domain 2
ANGPT2 angiopoietin 2
ANPEP alanyl (membrane) aminopeptidase
ANXA1 annexin A1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX4 brain expressed, X-linked 4
BMP4 bone morphogenetic protein 4
BPHL biphenyl hydrolase-like (serine hydrolase)
CA2 carbonic anhydrase II
CASP1 caspase 1, apoptosis-related cysteine peptidase
CD40 CD40 molecule, TNF receptor superfamily member 5
CD52 CD52 molecule
CECR1 cat eye syndrome chromosome region, candidate 1
CFB complement factor B
CHN1 chimerin 1
CLGN calmegin
COL11A1 collagen, type XI, alpha 1
COL4A6 collagen, type IV, alpha 6
COLEC12 collectin sub-family member 12
CRABP2 cellular retinoic acid binding protein 2
CSTA cystatin A (stefin A)
DEFA5 defensin, alpha 5, Paneth cell-specific
DENND1B DENN/MADD domain containing 1B
DPT dermatopontin
EIF4A1 eukaryotic translation initiation factor 4A1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FBLN1 fibulin 1
FILIP1L filamin A interacting protein 1-like
FN1 fibronectin 1
GJA1 gap junction protein, alpha 1, 43kDa
GOLGA8A golgin A8 family, member A
GREM1 gremlin 1, DAN family BMP antagonist
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HRASLS HRAS-like suppressor
KRT5 keratin 5, type II
MATN2 matrilin 2
MME membrane metallo-endopeptidase
MPPED2 metallophosphoesterase domain containing 2
MSMB microseminoprotein, beta-
MT1X metallothionein 1X
MXRA5 matrix-remodelling associated 5
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDGFC platelet derived growth factor C
PEG10 paternally expressed 10
PHGDH phosphoglycerate dehydrogenase
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLCL1 phospholipase C-like 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTN pleiotrophin
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
REG1A regenerating islet-derived 1 alpha
RGCC regulator of cell cycle
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPL10 ribosomal protein L10
S100A8 S100 calcium binding protein A8
SELE selectin E
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SSPN sarcospan
STAB1 stabilin 1
STON1 stonin 1
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TKTL1 transketolase-like 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
VEGFA vascular endothelial growth factor A
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
ZNF131 zinc finger protein 131
ZNF331 zinc finger protein 331
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AIM2 absent in melanoma 2
AMD1 adenosylmethionine decarboxylase 1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA3 annexin A3
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BASP1 brain abundant, membrane attached signal protein 1
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CD24 CD24 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHI3L2 chitinase 3-like 2
CHPT1 choline phosphotransferase 1
CLDN3 claudin 3
CLIC4 chloride intracellular channel 4
CSRP1 cysteine and glycine-rich protein 1
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DLC1 DLC1 Rho GTPase activating protein
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
HACD1 3-hydroxyacyl-CoA dehydratase 1
HOPX HOP homeobox
INPP5F inositol polyphosphate-5-phosphatase F
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
MAP7 microtubule-associated protein 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MRPS33 mitochondrial ribosomal protein S33
MXRA7 matrix-remodelling associated 7
MYB v-myb avian myeloblastosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NEBL nebulette
NEK7 NIMA-related kinase 7
NFIB nuclear factor I/B
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NGRN neugrin, neurite outgrowth associated
NRN1 neuritin 1
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PCDH9 protocadherin 9
PPARG peroxisome proliferator-activated receptor gamma
PROM1 prominin 1
PSPH phosphoserine phosphatase
QDPR quinoid dihydropteridine reductase
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
REEP5 receptor accessory protein 5
REXO2 RNA exonuclease 2
RHOB ras homolog family member B
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S100A12 S100 calcium binding protein A12
SFTPB surfactant protein B
SHOC2 soc-2 suppressor of clear homolog (C. elegans)
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLPI secretory leukocyte peptidase inhibitor
TESC tescalcin
TFF3 trefoil factor 3 (intestinal)
TJP2 tight junction protein 2
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSPAN8 tetraspanin 8
UGCG UDP-glucose ceramide glucosyltransferase
WIPI1 WD repeat domain, phosphoinositide interacting 1
WSB2 WD repeat and SOCS box containing 2