BRD-A09472452_flecainide_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-A09472452_flecainide_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
AGR2 anterior gradient 2
ALCAM activated leukocyte cell adhesion molecule
APOD apolipoprotein D
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BTG1 B-cell translocation gene 1, anti-proliferative
C3 complement component 3
C6ORF48 chromosome 6 open reading frame 48
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLGN calmegin
CLIC4 chloride intracellular channel 4
CST3 cystatin C
CSTA cystatin A (stefin A)
CTH cystathionine gamma-lyase
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DSP desmoplakin
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPRS glutamyl-prolyl-tRNA synthetase
FOLR1 folate receptor 1 (adult)
FOXO3 forkhead box O3
GARS glycyl-tRNA synthetase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
IARS isoleucyl-tRNA synthetase
IGFBP3 insulin-like growth factor binding protein 3
INHBA inhibin, beta A
INHBE inhibin, beta E
IRS2 insulin receptor substrate 2
KIAA0485 uncharacterized LOC57235
KRT7 keratin 7, type II
LMO2 LIM domain only 2 (rhombotin-like 1)
MARS methionyl-tRNA synthetase
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MKNK2 MAP kinase interacting serine/threonine kinase 2
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NUPR1 nuclear protein, transcriptional regulator, 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDE4DIP phosphodiesterase 4D interacting protein
PENK proenkephalin
PHGDH phosphoglycerate dehydrogenase
PSAT1 phosphoserine aminotransferase 1
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SCGB1D2 secretoglobin, family 1D, member 2
SCRG1 stimulator of chondrogenesis 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SH3YL1 SH3 and SYLF domain containing 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPATS2L spermatogenesis associated, serine-rich 2-like
STC2 stanniocalcin 2
TARS threonyl-tRNA synthetase
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM47 transmembrane protein 47
TPD52L1 tumor protein D52-like 1
TSC22D3 TSC22 domain family, member 3
WARS tryptophanyl-tRNA synthetase
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ANGPT1 angiopoietin 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKB aurora kinase B
CDC25A cell division cycle 25A
CHEK1 checkpoint kinase 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF1AX eukaryotic translation initiation factor 1A, X-linked
F2RL1 coagulation factor II (thrombin) receptor-like 1
FEN1 flap structure-specific endonuclease 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MRPS2 mitochondrial ribosomal protein S2
NRG1 neuregulin 1
NT5DC2 5'-nucleotidase domain containing 2
PCDH7 protocadherin 7
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
RRM2 ribonucleotide reductase M2
SLBP stem-loop binding protein
SMC1A structural maintenance of chromosomes 1A
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TUBB4B tubulin, beta 4B class IVb
XPO7 exportin 7