BRD-A09472452_flecainide_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

52 genes differentially expressed following the BRD-A09472452_flecainide_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALOX5 arachidonate 5-lipoxygenase
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CFD complement factor D (adipsin)
CP ceruloplasmin (ferroxidase)
CXADR coxsackie virus and adenovirus receptor
DDIT4 DNA-damage-inducible transcript 4
ENO2 enolase 2 (gamma, neuronal)
ETV5 ets variant 5
FGFR1 fibroblast growth factor receptor 1
FHL2 four and a half LIM domains 2
FOLR1 folate receptor 1 (adult)
GLRX glutaredoxin (thioltransferase)
GPM6B glycoprotein M6B
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMOX1 heme oxygenase 1
KDM3A lysine (K)-specific demethylase 3A
LMO2 LIM domain only 2 (rhombotin-like 1)
MMP7 matrix metallopeptidase 7
MSX1 msh homeobox 1
MT1F metallothionein 1F
MT1M metallothionein 1M
NQO1 NAD(P)H dehydrogenase, quinone 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLIN2 perilipin 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SOX4 SRY (sex determining region Y)-box 4
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
TNC tenascin C
UGDH UDP-glucose 6-dehydrogenase

decreased expression

Symbol Name
AMIGO2 adhesion molecule with Ig-like domain 2
CCL4 chemokine (C-C motif) ligand 4
CD52 CD52 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
FLRT3 fibronectin leucine rich transmembrane protein 3
G0S2 G0/G1 switch 2
GBP1 guanylate binding protein 1, interferon-inducible
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IL1B interleukin 1, beta
LIPA lipase A, lysosomal acid, cholesterol esterase
MMP12 matrix metallopeptidase 12
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RFTN1 raftlin, lipid raft linker 1
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
SULF1 sulfatase 1