BRD-A09472452_flecainide_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

34 genes differentially expressed following the BRD-A09472452_flecainide_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AARS alanyl-tRNA synthetase
C8ORF4 chromosome 8 open reading frame 4
CTH cystathionine gamma-lyase
DDIT4 DNA-damage-inducible transcript 4
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
KYNU kynureninase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PHGDH phosphoglycerate dehydrogenase
PLA2G16 phospholipase A2, group XVI
PRNP prion protein
PSAT1 phosphoserine aminotransferase 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TBC1D4 TBC1 domain family, member 4
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TRIB3 tribbles pseudokinase 3
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CCND2 cyclin D2
CNN3 calponin 3, acidic
CRELD2 cysteine-rich with EGF-like domains 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
GPNMB glycoprotein (transmembrane) nmb
GRB7 growth factor receptor-bound protein 7
IGFBP3 insulin-like growth factor binding protein 3
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
PBX3 pre-B-cell leukemia homeobox 3
PEG10 paternally expressed 10
TIMP3 TIMP metallopeptidase inhibitor 3
ZNF395 zinc finger protein 395