BRD-A09062839_Amyleine hydrochloride_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

123 genes differentially expressed following the BRD-A09062839_Amyleine hydrochloride_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AQP1 aquaporin 1 (Colton blood group)
C3 complement component 3
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CFB complement factor B
CGA glycoprotein hormones, alpha polypeptide
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLIC2 chloride intracellular channel 2
CLU clusterin
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
CP ceruloplasmin (ferroxidase)
CPD carboxypeptidase D
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CST7 cystatin F (leukocystatin)
CX3CR1 chemokine (C-X3-C motif) receptor 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKFZP586I1420 uncharacterized protein DKFZp586I1420
DLK1 delta-like 1 homolog (Drosophila)
DUSP2 dual specificity phosphatase 2
EGR3 early growth response 3
ENPEP glutamyl aminopeptidase (aminopeptidase A)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPCAM epithelial cell adhesion molecule
ESR1 estrogen receptor 1
FPR1 formyl peptide receptor 1
GAL galanin/GMAP prepropeptide
GBP1 guanylate binding protein 1, interferon-inducible
HBB hemoglobin, beta
IDO1 indoleamine 2,3-dioxygenase 1
ITM2A integral membrane protein 2A
KRT17 keratin 17, type I
LIPG lipase, endothelial
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP7 microtubule-associated protein 7
MUC1 mucin 1, cell surface associated
NID2 nidogen 2 (osteonidogen)
NPR3 natriuretic peptide receptor 3
OLFM1 olfactomedin 1
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PDE1A phosphodiesterase 1A, calmodulin-dependent
PHACTR2 phosphatase and actin regulator 2
PLAGL1 pleiomorphic adenoma gene-like 1
PROS1 protein S (alpha)
PRSS21 protease, serine, 21 (testisin)
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RSF1 remodeling and spacing factor 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB1D2 secretoglobin, family 1D, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLPI secretory leukocyte peptidase inhibitor
SRGN serglycin
STAR steroidogenic acute regulatory protein
SYK spleen tyrosine kinase
TACSTD2 tumor-associated calcium signal transducer 2
TDO2 tryptophan 2,3-dioxygenase
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TLR4 toll-like receptor 4
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACSL3 acyl-CoA synthetase long-chain family member 3
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADI1 acireductone dioxygenase 1
ANAPC13 anaphase promoting complex subunit 13
C9ORF3 chromosome 9 open reading frame 3
CAPRIN2 caprin family member 2
CAV1 caveolin 1, caveolae protein, 22kDa
CBR3 carbonyl reductase 3
CLTB clathrin, light chain B
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLC1 DLC1 Rho GTPase activating protein
DNM1L dynamin 1-like
DUSP22 dual specificity phosphatase 22
EIF5 eukaryotic translation initiation factor 5
FAM60A family with sequence similarity 60, member A
FBXO21 F-box protein 21
FHL1 four and a half LIM domains 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GADD45B growth arrest and DNA-damage-inducible, beta
HEBP2 heme binding protein 2
HOMER2 homer scaffolding protein 2
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXD1 homeobox D1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP6 insulin-like growth factor binding protein 6
ISG15 ISG15 ubiquitin-like modifier
ITGA6 integrin, alpha 6
ITM2C integral membrane protein 2C
LRP4 low density lipoprotein receptor-related protein 4
LRRC16A leucine rich repeat containing 16A
MMD monocyte to macrophage differentiation-associated
NR2F6 nuclear receptor subfamily 2, group F, member 6
PAWR PRKC, apoptosis, WT1, regulator
PLK2 polo-like kinase 2
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRPF4 pre-mRNA processing factor 4
RBM34 RNA binding motif protein 34
RFX5 regulatory factor X, 5 (influences HLA class II expression)
S100A10 S100 calcium binding protein A10
SMAD3 SMAD family member 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPOP speckle-type POZ protein
SRPX sushi-repeat containing protein, X-linked
TAGLN2 transgelin 2
TM4SF1 transmembrane 4 L six family member 1
TMSB15A thymosin beta 15a
TNIP1 TNFAIP3 interacting protein 1
TSPAN4 tetraspanin 4
UFM1 ubiquitin-fold modifier 1
VAT1 vesicle amine transport 1
XIST X inactive specific transcript (non-protein coding)