BRD-A09062839_Amyleine hydrochloride_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-A09062839_Amyleine hydrochloride_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK AHNAK nucleoprotein
CA1 carbonic anhydrase I
CA12 carbonic anhydrase XII
CFD complement factor D (adipsin)
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COLEC12 collectin sub-family member 12
CREB1 cAMP responsive element binding protein 1
DMXL2 Dmx-like 2
ETV1 ets variant 1
FBXL12 F-box and leucine-rich repeat protein 12
FNDC3B fibronectin type III domain containing 3B
GOLGA8A golgin A8 family, member A
GPD1L glycerol-3-phosphate dehydrogenase 1-like
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
KRT7 keratin 7, type II
KYNU kynureninase
LXN latexin
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MALL mal, T-cell differentiation protein-like
MSL1 male-specific lethal 1 homolog (Drosophila)
NEFL neurofilament, light polypeptide
NT5DC2 5'-nucleotidase domain containing 2
OLFML2A olfactomedin-like 2A
PEG3 paternally expressed 3
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PTX3 pentraxin 3, long
RAD23B RAD23 homolog B (S. cerevisiae)
RBPMS RNA binding protein with multiple splicing
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNH1 ribonuclease/angiogenin inhibitor 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLN sarcolipin
SOX11 SRY (sex determining region Y)-box 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TKT transketolase
TMEM30A transmembrane protein 30A
TPD52L1 tumor protein D52-like 1
TXN thioredoxin

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ATF3 activating transcription factor 3
CD69 CD69 molecule
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLCA1 chloride channel accessory 1
CPA3 carboxypeptidase A3 (mast cell)
CPB1 carboxypeptidase B1 (tissue)
DACH1 dachshund family transcription factor 1
EFNB2 ephrin-B2
EPAS1 endothelial PAS domain protein 1
EPHA4 EPH receptor A4
FAM107A family with sequence similarity 107, member A
FAM129A family with sequence similarity 129, member A
FGFR3 fibroblast growth factor receptor 3
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GPM6B glycoprotein M6B
GRIA2 glutamate receptor, ionotropic, AMPA 2
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ISG15 ISG15 ubiquitin-like modifier
LCN2 lipocalin 2
LTBP1 latent transforming growth factor beta binding protein 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MDK midkine (neurite growth-promoting factor 2)
MYLK myosin light chain kinase
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
ODC1 ornithine decarboxylase 1
OLFM4 olfactomedin 4
OSR2 odd-skipped related transciption factor 2
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PARP12 poly (ADP-ribose) polymerase family, member 12
PRDX2 peroxiredoxin 2
RABGAP1L RAB GTPase activating protein 1-like
SCGB2A1 secretoglobin, family 2A, member 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SNAI2 snail family zinc finger 2
SNAP25 synaptosomal-associated protein, 25kDa
SPARCL1 SPARC-like 1 (hevin)
SPINK4 serine peptidase inhibitor, Kazal type 4
SPON1 spondin 1, extracellular matrix protein
SYT1 synaptotagmin I
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
ZFP36L1 ZFP36 ring finger protein-like 1