BRD-A09056319_Alfuzosin hydrochloride_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

66 genes differentially expressed following the BRD-A09056319_Alfuzosin hydrochloride_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
AUTS2 autism susceptibility candidate 2
CA12 carbonic anhydrase XII
COL9A2 collagen, type IX, alpha 2
HLA-DOB major histocompatibility complex, class II, DO beta
HOXB6 homeobox B6
LDOC1 leucine zipper, down-regulated in cancer 1
LRMP lymphoid-restricted membrane protein
PAWR PRKC, apoptosis, WT1, regulator
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TGFBI transforming growth factor, beta-induced, 68kDa
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
ANXA1 annexin A1
ANXA7 annexin A7
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATF1 activating transcription factor 1
AZIN1 antizyme inhibitor 1
BEX4 brain expressed, X-linked 4
C1ORF115 chromosome 1 open reading frame 115
C3 complement component 3
CNN3 calponin 3, acidic
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CPB1 carboxypeptidase B1 (tissue)
CSTA cystatin A (stefin A)
CXCL12 chemokine (C-X-C motif) ligand 12
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMP1 epithelial membrane protein 1
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
FHL1 four and a half LIM domains 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
IGFBP7 insulin-like growth factor binding protein 7
KCTD12 potassium channel tetramerization domain containing 12
KRT19 keratin 19, type I
LAMB1 laminin, beta 1
LIMCH1 LIM and calponin homology domains 1
LUM lumican
LXN latexin
LYPLA1 lysophospholipase I
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MGP matrix Gla protein
MXRA5 matrix-remodelling associated 5
MYBPC1 myosin binding protein C, slow type
NAMPT nicotinamide phosphoribosyltransferase
NFIB nuclear factor I/B
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
PAK1IP1 PAK1 interacting protein 1
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
PTGER4 prostaglandin E receptor 4 (subtype EP4)
SGCE sarcoglycan, epsilon
SGK1 serum/glucocorticoid regulated kinase 1
SMC1A structural maintenance of chromosomes 1A
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TACSTD2 tumor-associated calcium signal transducer 2
TM4SF1 transmembrane 4 L six family member 1
TNS3 tensin 3
ZNF185 zinc finger protein 185 (LIM domain)