BRD-A08003242_RHODOMYRTOXIN B_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

144 genes differentially expressed following the BRD-A08003242_RHODOMYRTOXIN B_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACKR3 atypical chemokine receptor 3
ACLY ATP citrate lyase
ADM adrenomedullin
ALDOA aldolase A, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
APOA1 apolipoprotein A-I
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BACE2 beta-site APP-cleaving enzyme 2
BHLHE41 basic helix-loop-helix family, member e41
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BTG1 B-cell translocation gene 1, anti-proliferative
CALD1 caldesmon 1
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCND2 cyclin D2
CD24 CD24 molecule
CDK19 cyclin-dependent kinase 19
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLIC4 chloride intracellular channel 4
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
CTSE cathepsin E
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSP desmoplakin
EBP emopamil binding protein (sterol isomerase)
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM13A family with sequence similarity 13, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FGG fibrinogen gamma chain
FHL1 four and a half LIM domains 1
FOXO3 forkhead box O3
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GOLGA8A golgin A8 family, member A
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP3 insulin-like growth factor binding protein 3
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
INHBA inhibin, beta A
INHBB inhibin, beta B
INSIG1 insulin induced gene 1
KDM3A lysine (K)-specific demethylase 3A
KLF9 Kruppel-like factor 9
KRT17 keratin 17, type I
LDLR low density lipoprotein receptor
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARS methionyl-tRNA synthetase
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MXI1 MAX interactor 1, dimerization protein
MYO6 myosin VI
NDRG1 N-myc downstream regulated 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUPR1 nuclear protein, transcriptional regulator, 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POU2AF1 POU class 2 associating factor 1
PPARG peroxisome proliferator-activated receptor gamma
PSAP prosaposin
PSAT1 phosphoserine aminotransferase 1
SC5D sterol-C5-desaturase
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC4 syndecan 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SOX4 SRY (sex determining region Y)-box 4
SPAG4 sperm associated antigen 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SQLE squalene epoxidase
STC2 stanniocalcin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM97 transmembrane protein 97
TSC22D3 TSC22 domain family, member 3
TTC3 tetratricopeptide repeat domain 3
UFM1 ubiquitin-fold modifier 1
VCAN versican
VEGFA vascular endothelial growth factor A
VGLL4 vestigial-like family member 4
XPOT exportin, tRNA

decreased expression

Symbol Name
ACP5 acid phosphatase 5, tartrate resistant
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
CCNF cyclin F
CD320 CD320 molecule
CDC20 cell division cycle 20
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CFB complement factor B
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DPYD dihydropyrimidine dehydrogenase
ENDOD1 endonuclease domain containing 1
FBLN1 fibulin 1
FBLN5 fibulin 5
FMO1 flavin containing monooxygenase 1
GPM6B glycoprotein M6B
H2BFS H2B histone family, member S (pseudogene)
HES1 hes family bHLH transcription factor 1
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HOXB7 homeobox B7
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LRRC17 leucine rich repeat containing 17
LYPD1 LY6/PLAUR domain containing 1
MAN1C1 mannosidase, alpha, class 1C, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
PODXL podocalyxin-like
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
SLIRP SRA stem-loop interacting RNA binding protein
SPARCL1 SPARC-like 1 (hevin)
SRGN serglycin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
WWTR1 WW domain containing transcription regulator 1