BRD-A08003242_RHODOMYRTOXIN B_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

297 genes differentially expressed following the BRD-A08003242_RHODOMYRTOXIN B_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACBD3 acyl-CoA binding domain containing 3
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
ANKRD10 ankyrin repeat domain 10
APOLD1 apolipoprotein L domain containing 1
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BPGM 2,3-bisphosphoglycerate mutase
BTG1 B-cell translocation gene 1, anti-proliferative
CANX calnexin
CARS cysteinyl-tRNA synthetase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBS cystathionine-beta-synthase
CCDC28A coiled-coil domain containing 28A
CCDC92 coiled-coil domain containing 92
CCNA1 cyclin A1
CCPG1 cell cycle progression 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CLCN3 chloride channel, voltage-sensitive 3
COPB2 coatomer protein complex, subunit beta 2 (beta prime)
CPA3 carboxypeptidase A3 (mast cell)
CTH cystathionine gamma-lyase
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAP death-associated protein
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DMXL2 Dmx-like 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP5 dual specificity phosphatase 5
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGFR epidermal growth factor receptor
EIF1 eukaryotic translation initiation factor 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EPAS1 endothelial PAS domain protein 1
EPRS glutamyl-prolyl-tRNA synthetase
FAM134B family with sequence similarity 134, member B
FOXO4 forkhead box O4
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GLS glutaminase
GOLGA5 golgin A5
GOLGB1 golgin B1
GOLT1B golgi transport 1B
GPM6B glycoprotein M6B
GTPBP2 GTP binding protein 2
GULP1 GULP, engulfment adaptor PTB domain containing 1
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HDLBP high density lipoprotein binding protein
HECA headcase homolog (Drosophila)
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HYOU1 hypoxia up-regulated 1
ICAM1 intercellular adhesion molecule 1
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IFRD1 interferon-related developmental regulator 1
IGF2R insulin-like growth factor 2 receptor
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL6 interleukin 6
INSIG1 insulin induced gene 1
ITM2C integral membrane protein 2C
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KIF1A kinesin family member 1A
KLF9 Kruppel-like factor 9
KLHL24 kelch-like family member 24
KRT6B keratin 6B, type II
LARP6 La ribonucleoprotein domain family, member 6
LGALS4 lectin, galactoside-binding, soluble, 4
LIMCH1 LIM and calponin homology domains 1
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARS methionyl-tRNA synthetase
MIR22HG MIR22 host gene
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
N4BP2L2 NEDD4 binding protein 2-like 2
NCOA3 nuclear receptor coactivator 3
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NPC1 Niemann-Pick disease, type C1
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
OSER1 oxidative stress responsive serine-rich 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE4DIP phosphodiesterase 4D interacting protein
PDGFC platelet derived growth factor C
PHF1 PHD finger protein 1
PHGDH phosphoglycerate dehydrogenase
PID1 phosphotyrosine interaction domain containing 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAP prosaposin
PSAT1 phosphoserine aminotransferase 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPRO protein tyrosine phosphatase, receptor type, O
PTX3 pentraxin 3, long
RAB9A RAB9A, member RAS oncogene family
RABAC1 Rab acceptor 1 (prenylated)
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RCAN1 regulator of calcineurin 1
RHOQ ras homolog family member Q
RIOK3 RIO kinase 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF19B ring finger protein 19B
RRAGC Ras-related GTP binding C
RRAGD Ras-related GTP binding D
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A2 secretoglobin, family 2A, member 2
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SEC61G Sec61 gamma subunit
SEC62 SEC62 homolog (S. cerevisiae)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SEPP1 selenoprotein P, plasma, 1
SERINC3 serine incorporator 3
SERINC5 serine incorporator 5
SERP1 stress-associated endoplasmic reticulum protein 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMOX spermine oxidase
SPINK1 serine peptidase inhibitor, Kazal type 1
SRGN serglycin
TFE3 transcription factor binding to IGHM enhancer 3
TFG TRK-fused gene
TMEM39A transmembrane protein 39A
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPD52L1 tumor protein D52-like 1
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
UGDH UDP-glucose 6-dehydrogenase
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase
YIPF3 Yip1 domain family, member 3
YPEL5 yippee-like 5 (Drosophila)
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AK4 adenylate kinase 4
AKAP12 A kinase (PRKA) anchor protein 12
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ATAD2 ATPase family, AAA domain containing 2
BAG3 BCL2-associated athanogene 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C20ORF27 chromosome 20 open reading frame 27
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCND1 cyclin D1
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CEP55 centrosomal protein 55kDa
CHEK1 checkpoint kinase 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL10 chemokine (C-X-C motif) ligand 10
DHFR dihydrofolate reductase
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMP2 epithelial membrane protein 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCI Fanconi anemia, complementation group I
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FZD6 frizzled class receptor 6
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAL galanin/GMAP prepropeptide
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPI glucose-6-phosphate isomerase
GRWD1 glutamate-rich WD repeat containing 1
H2AFX H2A histone family, member X
HAT1 histone acetyltransferase 1
HIST1H2BH histone cluster 1, H2bh
HN1 hematological and neurological expressed 1
HNRNPM heterogeneous nuclear ribonucleoprotein M
HOXA10 homeobox A10
HOXB7 homeobox B7
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA1A heat shock 70kDa protein 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF20A kinesin family member 20A
KRT19 keratin 19, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARCKSL1 MARCKS-like 1
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MSH2 mutS homolog 2
MTERF3 mitochondrial transcription termination factor 3
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NOL11 nucleolar protein 11
NR2F1 nuclear receptor subfamily 2, group F, member 1
NREP neuronal regeneration related protein
NUP210 nucleoporin 210kDa
OAT ornithine aminotransferase
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PCP4 Purkinje cell protein 4
PLBD1 phospholipase B domain containing 1
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCD protein kinase C, delta
RAD51 RAD51 recombinase
RANBP1 RAN binding protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RGS2 regulator of G-protein signaling 2
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A7 S100 calcium binding protein A7
SEPW1 selenoprotein W, 1
SHCBP1 SHC SH2-domain binding protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC19A1 solute carrier family 19 (folate transporter), member 1
SMC2 structural maintenance of chromosomes 2
SOX4 SRY (sex determining region Y)-box 4
SPC25 SPC25, NDC80 kinetochore complex component
SPDEF SAM pointed domain containing ETS transcription factor
SRM spermidine synthase
SRPX sushi-repeat containing protein, X-linked
SRSF2 serine/arginine-rich splicing factor 2
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACSTD2 tumor-associated calcium signal transducer 2
TFDP1 transcription factor Dp-1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TIMELESS timeless circadian clock
TMEM97 transmembrane protein 97
TMPO thymopoietin
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIB2 tribbles pseudokinase 2
TRIP13 thyroid hormone receptor interactor 13
TYMS thymidylate synthetase
UBE2N ubiquitin-conjugating enzyme E2N
UNG uracil-DNA glycosylase
VCAN versican
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein