BRD-A08003242_RHODOMYRTOXIN B_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-A08003242_RHODOMYRTOXIN B_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ANKRD10 ankyrin repeat domain 10
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BTG1 B-cell translocation gene 1, anti-proliferative
CAPN2 calpain 2, (m/II) large subunit
CBS cystathionine-beta-synthase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
COPA coatomer protein complex, subunit alpha
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
EPAS1 endothelial PAS domain protein 1
FAM129A family with sequence similarity 129, member A
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GATAD1 GATA zinc finger domain containing 1
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GPNMB glycoprotein (transmembrane) nmb
HBEGF heparin-binding EGF-like growth factor
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
JUNB jun B proto-oncogene
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K5 mitogen-activated protein kinase kinase 5
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MCL1 myeloid cell leukemia 1
MSMO1 methylsterol monooxygenase 1
N4BP2L2 NEDD4 binding protein 2-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NT5E 5'-nucleotidase, ecto (CD73)
PDE4C phosphodiesterase 4C, cAMP-specific
PDZK1IP1 PDZK1 interacting protein 1
PHGDH phosphoglycerate dehydrogenase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
RGCC regulator of cell cycle
RHOB ras homolog family member B
RND3 Rho family GTPase 3
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TFPI2 tissue factor pathway inhibitor 2
TGFA transforming growth factor, alpha
TNIP1 TNFAIP3 interacting protein 1
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TXNRD1 thioredoxin reductase 1
VEGFA vascular endothelial growth factor A
WAC WW domain containing adaptor with coiled-coil
WIPI1 WD repeat domain, phosphoinositide interacting 1
WSB1 WD repeat and SOCS box containing 1
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZKSCAN1 zinc finger with KRAB and SCAN domains 1

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
AGR2 anterior gradient 2
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASRGL1 asparaginase like 1
B3GNT1
BAG3 BCL2-associated athanogene 3
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
COMMD8 COMM domain containing 8
CRYZ crystallin, zeta (quinone reductase)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EMP2 epithelial membrane protein 2
FEN1 flap structure-specific endonuclease 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
HAT1 histone acetyltransferase 1
KIAA0101 KIAA0101
LAPTM4B lysosomal protein transmembrane 4 beta
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MYCBP MYC binding protein
PCNA proliferating cell nuclear antigen
PGAM1 phosphoglycerate mutase 1 (brain)
PLK1 polo-like kinase 1
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PTDSS1 phosphatidylserine synthase 1
PTTG1 pituitary tumor-transforming 1
RBP1 retinol binding protein 1, cellular
RPA3 replication protein A3, 14kDa
SEPW1 selenoprotein W, 1
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TMEM109 transmembrane protein 109
TMEM14A transmembrane protein 14A
TMEM70 transmembrane protein 70
TSPYL5 TSPY-like 5
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein