BRD-A08003242_RHODOMYRTOXIN B_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

173 genes differentially expressed following the BRD-A08003242_RHODOMYRTOXIN B_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACBD3 acyl-CoA binding domain containing 3
ADM adrenomedullin
ANKRD12 ankyrin repeat domain 12
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAD BCL2-associated agonist of cell death
BCL2A1 BCL2-related protein A1
BCL3 B-cell CLL/lymphoma 3
BIRC3 baculoviral IAP repeat containing 3
BSG basigin (Ok blood group)
CARS cysteinyl-tRNA synthetase
CAST calpastatin
CCL20 chemokine (C-C motif) ligand 20
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP5 dual specificity phosphatase 5
EHD1 EH-domain containing 1
ENO2 enolase 2 (gamma, neuronal)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FBN2 fibrillin 2
FNDC3B fibronectin type III domain containing 3B
FOXO3 forkhead box O3
FSD1 fibronectin type III and SPRY domain containing 1
GADD45B growth arrest and DNA-damage-inducible, beta
GNPDA1 glucosamine-6-phosphate deaminase 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOOK2 hook microtubule-tethering protein 2
HSPA13 heat shock protein 70kDa family, member 13
ICAM1 intercellular adhesion molecule 1
IFI27 interferon, alpha-inducible protein 27
IL1A interleukin 1, alpha
IL32 interleukin 32
IRF1 interferon regulatory factor 1
ISG20 interferon stimulated exonuclease gene 20kDa
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JUNB jun B proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KLF10 Kruppel-like factor 10
KYNU kynureninase
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAPK6 mitogen-activated protein kinase 6
MCL1 myeloid cell leukemia 1
MGLL monoglyceride lipase
MIR22HG MIR22 host gene
MKNK2 MAP kinase interacting serine/threonine kinase 2
MKRN1 makorin ring finger protein 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFIL3 nuclear factor, interleukin 3 regulated
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPC1 Niemann-Pick disease, type C1
NR1D2 nuclear receptor subfamily 1, group D, member 2
OPTN optineurin
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PLAUR plasminogen activator, urokinase receptor
RAB5A RAB5A, member RAS oncogene family
RAB6A RAB6A, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
RBM47 RNA binding motif protein 47
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIOK3 RIO kinase 3
RIPK2 receptor-interacting serine-threonine kinase 2
RNMT RNA (guanine-7-) methyltransferase
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELE selectin E
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SMAD3 SMAD family member 3
SOD2 superoxide dismutase 2, mitochondrial
SPAG9 sperm associated antigen 9
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRED2 sprouty-related, EVH1 domain containing 2
STC2 stanniocalcin 2
TAGLN2 transgelin 2
TKTL1 transketolase-like 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNIP1 TNFAIP3 interacting protein 1
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UBE2H ubiquitin-conjugating enzyme E2H
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
ZC3H12A zinc finger CCCH-type containing 12A

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
AEBP1 AE binding protein 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ASRGL1 asparaginase like 1
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BGN biglycan
CD200 CD200 molecule
CDC25A cell division cycle 25A
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CLDN10 claudin 10
CRABP2 cellular retinoic acid binding protein 2
CRISP3 cysteine-rich secretory protein 3
CTNND1 catenin (cadherin-associated protein), delta 1
EFNB2 ephrin-B2
ELAC2 elaC ribonuclease Z 2
ESR1 estrogen receptor 1
GAS1 growth arrest-specific 1
H2AFX H2A histone family, member X
HEPH hephaestin
HIST1H1C histone cluster 1, H1c
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HSPA1A heat shock 70kDa protein 1A
HSPG2 heparan sulfate proteoglycan 2
IFI16 interferon, gamma-inducible protein 16
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ITM2A integral membrane protein 2A
KLK6 kallikrein-related peptidase 6
KLK7 kallikrein-related peptidase 7
KLK8 kallikrein-related peptidase 8
KRT14 keratin 14, type I
KRT6A keratin 6A, type II
LCN2 lipocalin 2
LY6E lymphocyte antigen 6 complex, locus E
MCM3 minichromosome maintenance complex component 3
MEIS2 Meis homeobox 2
MNDA myeloid cell nuclear differentiation antigen
MSH6 mutS homolog 6
MYB v-myb avian myeloblastosis viral oncogene homolog
NPIPB3 nuclear pore complex interacting protein family, member B3
NPTX2 neuronal pentraxin II
OLFM4 olfactomedin 4
PCP4 Purkinje cell protein 4
PI3 peptidase inhibitor 3, skin-derived
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PUF60 poly-U binding splicing factor 60KDa
RBP1 retinol binding protein 1, cellular
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RGS4 regulator of G-protein signaling 4
S100A8 S100 calcium binding protein A8
SCAND1 SCAN domain containing 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SLPI secretory leukocyte peptidase inhibitor
SPON1 spondin 1, extracellular matrix protein
SRSF7 serine/arginine-rich splicing factor 7
SST somatostatin
STEAP1 six transmembrane epithelial antigen of the prostate 1
TACSTD2 tumor-associated calcium signal transducer 2
TCF4 transcription factor 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TRIB2 tribbles pseudokinase 2
WT1 Wilms tumor 1
ZNF185 zinc finger protein 185 (LIM domain)