BRD-A08003242_RHODOMYRTOXIN B_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-A08003242_RHODOMYRTOXIN B_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADORA2B adenosine A2b receptor
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALOX5 arachidonate 5-lipoxygenase
ANKRD10 ankyrin repeat domain 10
ASNS asparagine synthetase (glutamine-hydrolyzing)
CA1 carbonic anhydrase I
CA12 carbonic anhydrase XII
CAPG capping protein (actin filament), gelsolin-like
CD177 CD177 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CLU clusterin
COCH cochlin
COPA coatomer protein complex, subunit alpha
CST3 cystatin C
CTSH cathepsin H
CXCL13 chemokine (C-X-C motif) ligand 13
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLK1 delta-like 1 homolog (Drosophila)
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP5 dual specificity phosphatase 5
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FAM129A family with sequence similarity 129, member A
FBN2 fibrillin 2
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GRIA2 glutamate receptor, ionotropic, AMPA 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HK2 hexokinase 2
HMOX1 heme oxygenase 1
IFI30 interferon, gamma-inducible protein 30
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV1-40 immunoglobulin lambda variable 1-40
IGLV2-23 immunoglobulin lambda variable 2-23
IL32 interleukin 32
INSIG1 insulin induced gene 1
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
LDLR low density lipoprotein receptor
LIMA1 LIM domain and actin binding 1
LYRM4 LYR motif containing 4
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MTMR11 myotubularin related protein 11
MYO6 myosin VI
NAMPT nicotinamide phosphoribosyltransferase
NT5DC2 5'-nucleotidase domain containing 2
NUPR1 nuclear protein, transcriptional regulator, 1
PBX1 pre-B-cell leukemia homeobox 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE4A phosphodiesterase 4A, cAMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PHGDH phosphoglycerate dehydrogenase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POU2AF1 POU class 2 associating factor 1
PSAP prosaposin
PSD3 pleckstrin and Sec7 domain containing 3
PYCR1 pyrroline-5-carboxylate reductase 1
RAB20 RAB20, member RAS oncogene family
RAB31 RAB31, member RAS oncogene family
RBM47 RNA binding motif protein 47
RNMT RNA (guanine-7-) methyltransferase
SEC63 SEC63 homolog (S. cerevisiae)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC38A1 solute carrier family 38, member 1
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TIMP1 TIMP metallopeptidase inhibitor 1
TLR4 toll-like receptor 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIB3 tribbles pseudokinase 3
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
ZBED2 zinc finger, BED-type containing 2

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ALB albumin
ASCL1 achaete-scute family bHLH transcription factor 1
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
BAMBI BMP and activin membrane-bound inhibitor
CADM1 cell adhesion molecule 1
CBR3 carbonyl reductase 3
CDC42 cell division cycle 42
CHMP6 charged multivesicular body protein 6
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
EDN1 endothelin 1
EDNRB endothelin receptor type B
EGF epidermal growth factor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GREM1 gremlin 1, DAN family BMP antagonist
HACD2 3-hydroxyacyl-CoA dehydratase 2
HAL histidine ammonia-lyase
HOXC6 homeobox C6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
LAPTM4B lysosomal protein transmembrane 4 beta
MAN1A1 mannosidase, alpha, class 1A, member 1
MFAP3L microfibrillar-associated protein 3-like
MFAP5 microfibrillar associated protein 5
MGAM maltase-glucoamylase
MYO1B myosin IB
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PDGFD platelet derived growth factor D
PLS3 plastin 3
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
RCAN1 regulator of calcineurin 1
RGS4 regulator of G-protein signaling 4
SRSF6 serine/arginine-rich splicing factor 6
SYNGR1 synaptogyrin 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TUBA4A tubulin, alpha 4a
TYRP1 tyrosinase-related protein 1
UBE2E3 ubiquitin-conjugating enzyme E2E 3