BRD-A08003242_RHODOMYRTOXIN B_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

268 genes differentially expressed following the BRD-A08003242_RHODOMYRTOXIN B_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
AHNAK2 AHNAK nucleoprotein 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ANXA3 annexin A3
APOD apolipoprotein D
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BTG3 BTG family, member 3
CAPG capping protein (actin filament), gelsolin-like
CARS cysteinyl-tRNA synthetase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD44 CD44 molecule (Indian blood group)
CD79A CD79a molecule, immunoglobulin-associated alpha
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN3 claudin 3
CPM carboxypeptidase M
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DCLK1 doublecortin-like kinase 1
DDIT3 DNA-damage-inducible transcript 3
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DFNA5 deafness, autosomal dominant 5
DHRS7 dehydrogenase/reductase (SDR family) member 7
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSTN destrin (actin depolymerizing factor)
DUSP5 dual specificity phosphatase 5
EGFR epidermal growth factor receptor
EIF1B eukaryotic translation initiation factor 1B
EPAS1 endothelial PAS domain protein 1
FABP4 fatty acid binding protein 4, adipocyte
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GPM6A glycoprotein M6A
GPM6B glycoprotein M6B
GRB10 growth factor receptor-bound protein 10
GRIA2 glutamate receptor, ionotropic, AMPA 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HK2 hexokinase 2
HLA-E major histocompatibility complex, class I, E
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
INSIG1 insulin induced gene 1
ITGA6 integrin, alpha 6
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLHL24 kelch-like family member 24
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBNL2 muscleblind-like splicing regulator 2
MEOX2 mesenchyme homeobox 2
MET MET proto-oncogene, receptor tyrosine kinase
MME membrane metallo-endopeptidase
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSMO1 methylsterol monooxygenase 1
MTMR11 myotubularin related protein 11
MYO1D myosin ID
NAV2 neuron navigator 2
NEBL nebulette
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NPC1 Niemann-Pick disease, type C1
NPIPB3 nuclear pore complex interacting protein family, member B3
NUPR1 nuclear protein, transcriptional regulator, 1
PEA15 phosphoprotein enriched in astrocytes 15
PFDN2 prefoldin subunit 2
PHGDH phosphoglycerate dehydrogenase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLCB4 phospholipase C, beta 4
PPAP2B phosphatidic acid phosphatase type 2B
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRUNE2 prune homolog 2 (Drosophila)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTX3 pentraxin 3, long
PYCR1 pyrroline-5-carboxylate reductase 1
PYGB phosphorylase, glycogen; brain
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RTN1 reticulon 1
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A2 secretoglobin, family 2A, member 2
SDCBP syndecan binding protein (syntenin)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SQLE squalene epoxidase
SRPX sushi-repeat containing protein, X-linked
ST18 suppression of tumorigenicity 18, zinc finger
STC2 stanniocalcin 2
STX1A syntaxin 1A (brain)
SYNJ2 synaptojanin 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TFF1 trefoil factor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
UPP1 uridine phosphorylase 1
VAT1 vesicle amine transport 1
VEGFA vascular endothelial growth factor A
VWF von Willebrand factor
XIST X inactive specific transcript (non-protein coding)
YARS tyrosyl-tRNA synthetase
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BLM Bloom syndrome, RecQ helicase-like
BRCA1 breast cancer 1, early onset
BST2 bone marrow stromal cell antigen 2
CBX3 chromobox homolog 3
CBX5 chromobox homolog 5
CCNA2 cyclin A2
CCND3 cyclin D3
CCNF cyclin F
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHAF1A chromatin assembly factor 1, subunit A (p150)
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CHMP6 charged multivesicular body protein 6
CHSY1 chondroitin sulfate synthase 1
COL5A1 collagen, type V, alpha 1
CRIP1 cysteine-rich protein 1 (intestinal)
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL14 chemokine (C-X-C motif) ligand 14
CYBA cytochrome b-245, alpha polypeptide
DEFB1 defensin, beta 1
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DOK4 docking protein 4
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
EMP2 epithelial membrane protein 2
ERI2 ERI1 exoribonuclease family member 2
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
H2AFX H2A histone family, member X
HAT1 histone acetyltransferase 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP3 insulin-like growth factor binding protein 3
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IRX5 iroquois homeobox 5
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
LEF1 lymphoid enhancer-binding factor 1
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LUM lumican
LYPD1 LY6/PLAUR domain containing 1
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MGST2 microsomal glutathione S-transferase 2
MKI67 marker of proliferation Ki-67
MYCBP MYC binding protein
MYD88 myeloid differentiation primary response 88
MYH10 myosin, heavy chain 10, non-muscle
NCAPG2 non-SMC condensin II complex, subunit G2
NPY neuropeptide Y
NQO1 NAD(P)H dehydrogenase, quinone 1
NTS neurotensin
NUP210 nucleoporin 210kDa
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PKM pyruvate kinase, muscle
PLK2 polo-like kinase 2
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PPIF peptidylprolyl isomerase F
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PRC1 protein regulator of cytokinesis 1
PRSS23 protease, serine, 23
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PSPH phosphoserine phosphatase
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PXDN peroxidasin
RAB11A RAB11A, member RAS oncogene family
RAD51 RAD51 recombinase
RBP1 retinol binding protein 1, cellular
RFC5 replication factor C (activator 1) 5, 36.5kDa
RMI1 RecQ mediated genome instability 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPA3 replication protein A3, 14kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
SFPQ splicing factor proline/glutamine-rich
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SMAD1 SMAD family member 1
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPRR1A small proline-rich protein 1A
SRSF6 serine/arginine-rich splicing factor 6
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TESC tescalcin
TFDP1 transcription factor Dp-1
TK1 thymidine kinase 1, soluble
TMEM14A transmembrane protein 14A
TMEM2 transmembrane protein 2
TMOD1 tropomodulin 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPGS2 tubulin polyglutamylase complex subunit 2
TRIP13 thyroid hormone receptor interactor 13
TSPAN13 tetraspanin 13
TSPYL5 TSPY-like 5
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TUSC3 tumor suppressor candidate 3
TXNDC9 thioredoxin domain containing 9
TYMS thymidylate synthetase
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UNG uracil-DNA glycosylase
UPK1B uroplakin 1B
VCAN versican
VRK1 vaccinia related kinase 1
WNT5A wingless-type MMTV integration site family, member 5A
ZWINT ZW10 interacting kinetochore protein