BRD-A07932845_Methiothepin maleate_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

74 genes differentially expressed following the BRD-A07932845_Methiothepin maleate_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ATF3 activating transcription factor 3
CAST calpastatin
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CTSZ cathepsin Z
CXCL14 chemokine (C-X-C motif) ligand 14
FDPS farnesyl diphosphate synthase
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFNAR1 interferon (alpha, beta and omega) receptor 1
IL4R interleukin 4 receptor
INSIG1 insulin induced gene 1
KCTD12 potassium channel tetramerization domain containing 12
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
MARCKS myristoylated alanine-rich protein kinase C substrate
MSMO1 methylsterol monooxygenase 1
NRIP1 nuclear receptor interacting protein 1
NT5E 5'-nucleotidase, ecto (CD73)
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
RGS5 regulator of G-protein signaling 5
RPL37A ribosomal protein L37a
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A2 S100 calcium binding protein A2
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SQLE squalene epoxidase

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACPP acid phosphatase, prostate
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGR2 anterior gradient 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
CD27 CD27 molecule
COCH cochlin
CRISP3 cysteine-rich secretory protein 3
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CXCL12 chemokine (C-X-C motif) ligand 12
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
EGFL6 EGF-like-domain, multiple 6
EPCAM epithelial cell adhesion molecule
FOSL1 FOS-like antigen 1
GHR growth hormone receptor
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
LCN2 lipocalin 2
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIMCH1 LIM and calponin homology domains 1
LTF lactotransferrin
NKG7 natural killer cell granule protein 7
OLFM4 olfactomedin 4
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAC8 placenta-specific 8
PMP22 peripheral myelin protein 22
POU2AF1 POU class 2 associating factor 1
RAB31 RAB31, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RTN1 reticulon 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SFTPD surfactant protein D
TCL1A T-cell leukemia/lymphoma 1A
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)