BRD-A07932845_Methiothepin maleate_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

229 genes differentially expressed following the BRD-A07932845_Methiothepin maleate_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP12 A kinase (PRKA) anchor protein 12
ANO1 anoctamin 1, calcium activated chloride channel
APP amyloid beta (A4) precursor protein
BHLHE41 basic helix-loop-helix family, member e41
C10ORF10 chromosome 10 open reading frame 10
CALML3 calmodulin-like 3
CALR calreticulin
CAPN2 calpain 2, (m/II) large subunit
CCND2 cyclin D2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC5A C-type lectin domain family 5, member A
COL15A1 collagen, type XV, alpha 1
COL1A2 collagen, type I, alpha 2
COL6A2 collagen, type VI, alpha 2
CRISP3 cysteine-rich secretory protein 3
CST6 cystatin E/M
DPEP1 dipeptidase 1 (renal)
DSP desmoplakin
FN1 fibronectin 1
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GOLM1 golgi membrane protein 1
H1F0 H1 histone family, member 0
HAB1 B1 for mucin
HIST1H2BG histone cluster 1, H2bg
HLA-B major histocompatibility complex, class I, B
HOMER3 homer scaffolding protein 3
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IL1RN interleukin 1 receptor antagonist
IRF6 interferon regulatory factor 6
JUN jun proto-oncogene
KLK5 kallikrein-related peptidase 5
KRT6B keratin 6B, type II
LAMP1 lysosomal-associated membrane protein 1
LGALS1 lectin, galactoside-binding, soluble, 1
LPAR6 lysophosphatidic acid receptor 6
LTF lactotransferrin
MEX3D mex-3 RNA binding family member D
MMP11 matrix metallopeptidase 11
NRP1 neuropilin 1
PERP PERP, TP53 apoptosis effector
PLAU plasminogen activator, urokinase
RAB2A RAB2A, member RAS oncogene family
RBP1 retinol binding protein 1, cellular
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SFRP1 secreted frizzled-related protein 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLPI secretory leukocyte peptidase inhibitor
SOX9 SRY (sex determining region Y)-box 9
SPRR3 small proline-rich protein 3
SRSF5 serine/arginine-rich splicing factor 5
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TXNIP thioredoxin interacting protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADI1 acireductone dioxygenase 1
AGO3 argonaute RISC catalytic component 3
AGR2 anterior gradient 2
ALCAM activated leukocyte cell adhesion molecule
AMD1 adenosylmethionine decarboxylase 1
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
AQP3 aquaporin 3 (Gill blood group)
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BIRC5 baculoviral IAP repeat containing 5
C3ORF14 chromosome 3 open reading frame 14
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CBX1 chromobox homolog 1
CCND3 cyclin D3
CCNG1 cyclin G1
CD69 CD69 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CLU clusterin
COCH cochlin
COX11 COX11 cytochrome c oxidase copper chaperone
CP ceruloplasmin (ferroxidase)
CRYAB crystallin, alpha B
CSK c-src tyrosine kinase
CTH cystathionine gamma-lyase
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYTL1 cytokine-like 1
DARS aspartyl-tRNA synthetase
DCK deoxycytidine kinase
DCLK1 doublecortin-like kinase 1
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DLD dihydrolipoamide dehydrogenase
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding)
DMXL2 Dmx-like 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2
EBAG9 estrogen receptor binding site associated, antigen, 9
EED embryonic ectoderm development
EIF5A eukaryotic translation initiation factor 5A
EIF5B eukaryotic translation initiation factor 5B
ENOPH1 enolase-phosphatase 1
ERBB3 erb-b2 receptor tyrosine kinase 3
F12 coagulation factor XII (Hageman factor)
FAM134B family with sequence similarity 134, member B
FANCI Fanconi anemia, complementation group I
FERMT2 fermitin family member 2
FKBP3 FK506 binding protein 3, 25kDa
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GHITM growth hormone inducible transmembrane protein
GPX3 glutathione peroxidase 3
GRB14 growth factor receptor-bound protein 14
GRSF1 G-rich RNA sequence binding factor 1
HACD2 3-hydroxyacyl-CoA dehydratase 2
HEXIM1 hexamethylene bis-acetamide inducible 1
HIPK1 homeodomain interacting protein kinase 1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOXD1 homeobox D1
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
IVNS1ABP influenza virus NS1A binding protein
KIF2C kinesin family member 2C
KPNB1 karyopherin (importin) beta 1
KYNU kynureninase
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LUC7L3 LUC7-like 3 (S. cerevisiae)
LXN latexin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MARCKS myristoylated alanine-rich protein kinase C substrate
MET MET proto-oncogene, receptor tyrosine kinase
METTL5 methyltransferase like 5
MGLL monoglyceride lipase
MOAP1 modulator of apoptosis 1
MOB1A MOB kinase activator 1A
MRPL19 mitochondrial ribosomal protein L19
MSH6 mutS homolog 6
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC1 mucin 1, cell surface associated
NKTR natural killer cell triggering receptor
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUP62 nucleoporin 62kDa
OLFM1 olfactomedin 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBK PDZ binding kinase
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFC platelet derived growth factor C
PHF20 PHD finger protein 20
PLAC8 placenta-specific 8
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCD protein kinase C, delta
PRPF4 pre-mRNA processing factor 4
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RAB40B RAB40B, member RAS oncogene family
RABGGTB Rab geranylgeranyltransferase, beta subunit
RBM3 RNA binding motif (RNP1, RRM) protein 3
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
RNF138 ring finger protein 138, E3 ubiquitin protein ligase
RPL36AL ribosomal protein L36a-like
RPL37A ribosomal protein L37a
RPS27L ribosomal protein S27-like
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RRM1 ribonucleotide reductase M1
RRP1B ribosomal RNA processing 1B
SAR1A secretion associated, Ras related GTPase 1A
SF1 splicing factor 1
SFPQ splicing factor proline/glutamine-rich
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMS spermine synthase
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOD2 superoxide dismutase 2, mitochondrial
SPATA20 spermatogenesis associated 20
SRSF11 serine/arginine-rich splicing factor 11
STOM stomatin
TARBP1 TAR (HIV-1) RNA binding protein 1
TBC1D16 TBC1 domain family, member 16
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
THUMPD1 THUMP domain containing 1
TMEM106B transmembrane protein 106B
TOB1 transducer of ERBB2, 1
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAF5 TNF receptor-associated factor 5
TRAK2 trafficking protein, kinesin binding 2
TSNAX translin-associated factor X
TSPAN12 tetraspanin 12
TSPAN13 tetraspanin 13
TSPAN31 tetraspanin 31
TSPYL1 TSPY-like 1
TSPYL5 TSPY-like 5
TUBD1 tubulin, delta 1
TYMS thymidylate synthetase
UBE2B ubiquitin-conjugating enzyme E2B
UBE2G2 ubiquitin-conjugating enzyme E2G 2
USP1 ubiquitin specific peptidase 1
USP33 ubiquitin specific peptidase 33
WDR3 WD repeat domain 3
WRB tryptophan rich basic protein
WSB2 WD repeat and SOCS box containing 2
WWP1 WW domain containing E3 ubiquitin protein ligase 1
ZFAND1 zinc finger, AN1-type domain 1
ZMYM2 zinc finger, MYM-type 2
ZMYND8 zinc finger, MYND-type containing 8
ZNHIT6 zinc finger, HIT-type containing 6