BRD-A07000685_HYDROCORTISONE HEMISUCCINATE_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

155 genes differentially expressed following the BRD-A07000685_HYDROCORTISONE HEMISUCCINATE_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
ACSL5 acyl-CoA synthetase long-chain family member 5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
BCL6 B-cell CLL/lymphoma 6
BID BH3 interacting domain death agonist
C10ORF10 chromosome 10 open reading frame 10
C3 complement component 3
CD14 CD14 molecule
CD163 CD163 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD93 CD93 molecule
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CECR1 cat eye syndrome chromosome region, candidate 1
CFB complement factor B
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CIAPIN1 cytokine induced apoptosis inhibitor 1
COL1A2 collagen, type I, alpha 2
CP ceruloplasmin (ferroxidase)
CPM carboxypeptidase M
CRABP2 cellular retinoic acid binding protein 2
CSTA cystatin A (stefin A)
CYBB cytochrome b-245, beta polypeptide
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DPYD dihydropyrimidine dehydrogenase
DUSP1 dual specificity phosphatase 1
EIF5A eukaryotic translation initiation factor 5A
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F3 coagulation factor III (thromboplastin, tissue factor)
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FKBP5 FK506 binding protein 5
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FPR1 formyl peptide receptor 1
GADD45B growth arrest and DNA-damage-inducible, beta
GLUL glutamate-ammonia ligase
GSDMB gasdermin B
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IRS2 insulin receptor substrate 2
KLF4 Kruppel-like factor 4 (gut)
KLF9 Kruppel-like factor 9
KRT5 keratin 5, type II
LCN2 lipocalin 2
LTF lactotransferrin
MAOA monoamine oxidase A
MLPH melanophilin
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MT2A metallothionein 2A
MUC1 mucin 1, cell surface associated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NUPR1 nuclear protein, transcriptional regulator, 1
PDZK1IP1 PDZK1 interacting protein 1
PELI1 pellino E3 ubiquitin protein ligase 1
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PXDN peroxidasin
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100A10 S100 calcium binding protein A10
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLPI secretory leukocyte peptidase inhibitor
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SYBU syntabulin (syntaxin-interacting)
TLR4 toll-like receptor 4
TMSB15A thymosin beta 15a
TNNT1 troponin T type 1 (skeletal, slow)
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
ZBTB16 zinc finger and BTB domain containing 16
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1C2 aldo-keto reductase family 1, member C2
ARL4C ADP-ribosylation factor-like 4C
ARMCX6 armadillo repeat containing, X-linked 6
CADM1 cell adhesion molecule 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD58 CD58 molecule
COL14A1 collagen, type XIV, alpha 1
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CREM cAMP responsive element modulator
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DLK1 delta-like 1 homolog (Drosophila)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DST dystonin
DUSP10 dual specificity phosphatase 10
DUSP3 dual specificity phosphatase 3
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM129A family with sequence similarity 129, member A
FAM46A family with sequence similarity 46, member A
FGFR3 fibroblast growth factor receptor 3
FOLR1 folate receptor 1 (adult)
FZD7 frizzled class receptor 7
GCH1 GTP cyclohydrolase 1
GSTA4 glutathione S-transferase alpha 4
HEPH hephaestin
HES1 hes family bHLH transcription factor 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HSPA1A heat shock 70kDa protein 1A
IER3 immediate early response 3
IL6ST interleukin 6 signal transducer
ITGAV integrin, alpha V
ITM2A integral membrane protein 2A
LIMA1 LIM domain and actin binding 1
LRRN3 leucine rich repeat neuronal 3
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP7 microtubule-associated protein 7
MCOLN1 mucolipin 1
MORC4 MORC family CW-type zinc finger 4
NAV3 neuron navigator 3
NGRN neugrin, neurite outgrowth associated
NPAS2 neuronal PAS domain protein 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAGL1 pleiomorphic adenoma gene-like 1
PPIF peptidylprolyl isomerase F
PRSS2 protease, serine, 2 (trypsin 2)
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RPS27L ribosomal protein S27-like
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SMAD3 SMAD family member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX9 SRY (sex determining region Y)-box 9
SPATS2L spermatogenesis associated, serine-rich 2-like
SYNJ2 synaptojanin 2
SYT11 synaptotagmin XI
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF3 trefoil factor 3 (intestinal)
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
WSB1 WD repeat and SOCS box containing 1