BRD-A07000685_HYDROCORTISONE HEMISUCCINATE_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

98 genes differentially expressed following the BRD-A07000685_HYDROCORTISONE HEMISUCCINATE_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACSL1 acyl-CoA synthetase long-chain family member 1
ACTG2 actin, gamma 2, smooth muscle, enteric
ACTN1 actinin, alpha 1
AKAP12 A kinase (PRKA) anchor protein 12
C7 complement component 7
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CFD complement factor D (adipsin)
CNN1 calponin 1, basic, smooth muscle
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
F13A1 coagulation factor XIII, A1 polypeptide
FLNA filamin A, alpha
FOLR1 folate receptor 1 (adult)
GAL galanin/GMAP prepropeptide
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
HNRNPL heterogeneous nuclear ribonucleoprotein L
HSPA1A heat shock 70kDa protein 1A
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDM5D lysine (K)-specific demethylase 5D
LMOD1 leiomodin 1 (smooth muscle)
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MCOLN1 mucolipin 1
MYH11 myosin, heavy chain 11, smooth muscle
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NBEA neurobeachin
NR2F1 nuclear receptor subfamily 2, group F, member 1
PLIN2 perilipin 2
PLN phospholamban
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBPMS RNA binding protein with multiple splicing
RPS4Y1 ribosomal protein S4, Y-linked 1
SAP30 Sin3A-associated protein, 30kDa
SMCO4 single-pass membrane protein with coiled-coil domains 4
SORBS1 sorbin and SH3 domain containing 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRSF6 serine/arginine-rich splicing factor 6
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TIMP3 TIMP metallopeptidase inhibitor 3
TNS1 tensin 1
TPM2 tropomyosin 2 (beta)
TUBB2A tubulin, beta 2A class IIa

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALB albumin
APMAP adipocyte plasma membrane associated protein
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
ATF3 activating transcription factor 3
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BTG3 BTG family, member 3
CRABP2 cellular retinoic acid binding protein 2
CSRP2 cysteine and glycine-rich protein 2
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
GPM6A glycoprotein M6A
HIST1H4C histone cluster 1, H4c
IER5 immediate early response 5
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ITM2A integral membrane protein 2A
LAPTM4B lysosomal protein transmembrane 4 beta
LCN2 lipocalin 2
LOC100505650 uncharacterized LOC100505650
LPAR6 lysophosphatidic acid receptor 6
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MEST mesoderm specific transcript
MSLN mesothelin
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
ORM1 orosomucoid 1
P3H2 prolyl 3-hydroxylase 2
PEG10 paternally expressed 10
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLK2 polo-like kinase 2
PRKCI protein kinase C, iota
PTHLH parathyroid hormone-like hormone
RAB4A RAB4A, member RAS oncogene family
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RNASE6 ribonuclease, RNase A family, k6
RNF167 ring finger protein 167
S100P S100 calcium binding protein P
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TACSTD2 tumor-associated calcium signal transducer 2
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TNNC1 troponin C type 1 (slow)
TSPAN5 tetraspanin 5
UGCG UDP-glucose ceramide glucosyltransferase
XIST X inactive specific transcript (non-protein coding)