BRD-A06784547_MRS 1334_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-A06784547_MRS 1334_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
APP amyloid beta (A4) precursor protein
CA2 carbonic anhydrase II
CALML3 calmodulin-like 3
CASP2 caspase 2, apoptosis-related cysteine peptidase
CAST calpastatin
CD40 CD40 molecule, TNF receptor superfamily member 5
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHMP4A charged multivesicular body protein 4A
CPA3 carboxypeptidase A3 (mast cell)
CST1 cystatin SN
CSTA cystatin A (stefin A)
CYBB cytochrome b-245, beta polypeptide
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DSP desmoplakin
DST dystonin
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EXPH5 exophilin 5
GCLC glutamate-cysteine ligase, catalytic subunit
GJA1 gap junction protein, alpha 1, 43kDa
GPM6B glycoprotein M6B
GREM1 gremlin 1, DAN family BMP antagonist
GUSBP3 glucuronidase, beta pseudogene 3
HBB hemoglobin, beta
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HNRNPL heterogeneous nuclear ribonucleoprotein L
HPRT1 hypoxanthine phosphoribosyltransferase 1
IFI6 interferon, alpha-inducible protein 6
IKZF1 IKAROS family zinc finger 1 (Ikaros)
INSM1 insulinoma-associated 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
IVNS1ABP influenza virus NS1A binding protein
KRT14 keratin 14, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
LSP1 lymphocyte-specific protein 1
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MEST mesoderm specific transcript
MME membrane metallo-endopeptidase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NLRP2 NLR family, pyrin domain containing 2
NPIPB3 nuclear pore complex interacting protein family, member B3
NR1D2 nuclear receptor subfamily 1, group D, member 2
NTS neurotensin
NUTF2 nuclear transport factor 2
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PCP4 Purkinje cell protein 4
PERP PERP, TP53 apoptosis effector
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLXNC1 plexin C1
QPCT glutaminyl-peptide cyclotransferase
RND3 Rho family GTPase 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RUNX3 runt-related transcription factor 3
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERINC5 serine incorporator 5
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SFN stratifin
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX9 SRY (sex determining region Y)-box 9
SRSF6 serine/arginine-rich splicing factor 6
SSBP2 single-stranded DNA binding protein 2
STAR steroidogenic acute regulatory protein
TP63 tumor protein p63
TPD52 tumor protein D52
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TUBB2A tubulin, beta 2A class IIa
XYLT1 xylosyltransferase I
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZNF304 zinc finger protein 304
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AK1 adenylate kinase 1
APOD apolipoprotein D
AREG amphiregulin
BIN1 bridging integrator 1
C1S complement component 1, s subcomponent
CCL21 chemokine (C-C motif) ligand 21
CFI complement factor I
COBL cordon-bleu WH2 repeat protein
COL14A1 collagen, type XIV, alpha 1
CPVL carboxypeptidase, vitellogenic-like
CTSH cathepsin H
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FADS1 fatty acid desaturase 1
FAM216A family with sequence similarity 216, member A
FUCA1 fucosidase, alpha-L- 1, tissue
GPX3 glutathione peroxidase 3
HOXC6 homeobox C6
IGFBP4 insulin-like growth factor binding protein 4
IGL immunoglobulin lambda locus
LAMC1 laminin, gamma 1 (formerly LAMB2)
MGP matrix Gla protein
NMT1 N-myristoyltransferase 1
ODC1 ornithine decarboxylase 1
PEBP1 phosphatidylethanolamine binding protein 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
POSTN periostin, osteoblast specific factor
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SPINK1 serine peptidase inhibitor, Kazal type 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMEM97 transmembrane protein 97
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1