BRD-A06664848_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

151 genes differentially expressed following the BRD-A06664848_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADAM28 ADAM metallopeptidase domain 28
ARID5B AT rich interactive domain 5B (MRF1-like)
C1S complement component 1, s subcomponent
C6ORF62 chromosome 6 open reading frame 62
CALCA calcitonin-related polypeptide alpha
CCL19 chemokine (C-C motif) ligand 19
CCL20 chemokine (C-C motif) ligand 20
CD53 CD53 molecule
CD69 CD69 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFH complement factor H
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CLEC2B C-type lectin domain family 2, member B
CLU clusterin
COL9A3 collagen, type IX, alpha 3
CP ceruloplasmin (ferroxidase)
CSTA cystatin A (stefin A)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP22 dual specificity phosphatase 22
ELAVL1 ELAV like RNA binding protein 1
FAM162A family with sequence similarity 162, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FRZB frizzled-related protein
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HOXC10 homeobox C10
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
ICAM2 intercellular adhesion molecule 2
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFITM2 interferon induced transmembrane protein 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
ISG15 ISG15 ubiquitin-like modifier
KRT14 keratin 14, type I
LAPTM5 lysosomal protein transmembrane 5
LMO4 LIM domain only 4
LYRM1 LYR motif containing 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP19 matrix metallopeptidase 19
MSX1 msh homeobox 1
MT1F metallothionein 1F
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NGRN neugrin, neurite outgrowth associated
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
OLFML2B olfactomedin-like 2B
PCSK6 proprotein convertase subtilisin/kexin type 6
PDIA5 protein disulfide isomerase family A, member 5
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PSPH phosphoserine phosphatase
PTGDS prostaglandin D2 synthase 21kDa (brain)
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RBP1 retinol binding protein 1, cellular
REEP1 receptor accessory protein 1
RNF167 ring finger protein 167
RRAGD Ras-related GTP binding D
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SORBS3 sorbin and SH3 domain containing 3
SPAG4 sperm associated antigen 4
SPARCL1 SPARC-like 1 (hevin)
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TMEM176A transmembrane protein 176A
TRIM29 tripartite motif containing 29
TSPAN8 tetraspanin 8
WDR1 WD repeat domain 1

decreased expression

Symbol Name
AIM1 absent in melanoma 1
ANO3 anoctamin 3
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX2 armadillo repeat containing, X-linked 2
BCL6 B-cell CLL/lymphoma 6
BPHL biphenyl hydrolase-like (serine hydrolase)
BPTF bromodomain PHD finger transcription factor
CA12 carbonic anhydrase XII
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD1B CD1b molecule
CD1E CD1e molecule
CD200 CD200 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
DENND1B DENN/MADD domain containing 1B
DERA deoxyribose-phosphate aldolase (putative)
DPP4 dipeptidyl-peptidase 4
DPYD dihydropyrimidine dehydrogenase
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EXPH5 exophilin 5
FCHO1 FCH domain only 1
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5
GREB1 growth regulation by estrogen in breast cancer 1
GREM1 gremlin 1, DAN family BMP antagonist
HES1 hes family bHLH transcription factor 1
HIST1H2BD histone cluster 1, H2bd
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IL7R interleukin 7 receptor
IPO13 importin 13
ITFG1 integrin alpha FG-GAP repeat containing 1
KANK1 KN motif and ankyrin repeat domains 1
KRT81 keratin 81, type II
LDOC1 leucine zipper, down-regulated in cancer 1
LPAR2 lysophosphatidic acid receptor 2
LRRC15 leucine rich repeat containing 15
LXN latexin
MDFIC MyoD family inhibitor domain containing
MEIS2 Meis homeobox 2
MME membrane metallo-endopeptidase
MMP3 matrix metallopeptidase 3
MYH10 myosin, heavy chain 10, non-muscle
MYOF myoferlin
NELL2 NEL-like 2 (chicken)
NID2 nidogen 2 (osteonidogen)
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
P3H2 prolyl 3-hydroxylase 2
PAIP1 poly(A) binding protein interacting protein 1
PBX1 pre-B-cell leukemia homeobox 1
PCYOX1 prenylcysteine oxidase 1
PDZK1IP1 PDZK1 interacting protein 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRRC2C proline-rich coiled-coil 2C
PTPRK protein tyrosine phosphatase, receptor type, K
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBP4 retinol binding protein 4, plasma
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SCN3A sodium channel, voltage gated, type III alpha subunit
SFRP1 secreted frizzled-related protein 1
SLC16A4 solute carrier family 16, member 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SULF1 sulfatase 1
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TKT transketolase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPBG trophoblast glycoprotein
TRD T cell receptor delta locus
VCAN versican
WNT5A wingless-type MMTV integration site family, member 5A
ZNF91 zinc finger protein 91