BRD-A06352508_SB 218078_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

270 genes differentially expressed following the BRD-A06352508_SB 218078_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALB albumin
ANXA4 annexin A4
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
ARHGAP29 Rho GTPase activating protein 29
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
BEX4 brain expressed, X-linked 4
BHLHE41 basic helix-loop-helix family, member e41
BTG2 BTG family, member 2
BTG3 BTG family, member 3
C3 complement component 3
CA2 carbonic anhydrase II
CCL20 chemokine (C-C motif) ligand 20
CD44 CD44 molecule (Indian blood group)
CD52 CD52 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLCA4 chloride channel accessory 4
CLEC2B C-type lectin domain family 2, member B
COL11A1 collagen, type XI, alpha 1
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CPB1 carboxypeptidase B1 (tissue)
CTGF connective tissue growth factor
CTSK cathepsin K
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
DCK deoxycytidine kinase
DDIT4 DNA-damage-inducible transcript 4
EGR1 early growth response 1
EGR2 early growth response 2
EHF ets homologous factor
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPAS1 endothelial PAS domain protein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EVI2A ecotropic viral integration site 2A
FCGBP Fc fragment of IgG binding protein
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FKBP1A FK506 binding protein 1A, 12kDa
FOSL1 FOS-like antigen 1
FOXG1 forkhead box G1
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GJA1 gap junction protein, alpha 1, 43kDa
GLS glutaminase
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
H2AFY H2A histone family, member Y
H2BFS H2B histone family, member S (pseudogene)
HDAC9 histone deacetylase 9
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HLA-B major histocompatibility complex, class I, B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IER3 immediate early response 3
IGFBP7 insulin-like growth factor binding protein 7
IL32 interleukin 32
IL7R interleukin 7 receptor
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
JAG1 jagged 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0907 KIAA0907
KRT19 keratin 19, type I
KRT6B keratin 6B, type II
LAMP2 lysosomal-associated membrane protein 2
LDHB lactate dehydrogenase B
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS1 lectin, galactoside-binding, soluble, 1
LTB lymphotoxin beta (TNF superfamily, member 3)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOA monoamine oxidase A
MCTP1 multiple C2 domains, transmembrane 1
MEF2C myocyte enhancer factor 2C
MEIS2 Meis homeobox 2
MFAP5 microfibrillar associated protein 5
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
MSLN mesothelin
MVP major vault protein
MXRA5 matrix-remodelling associated 5
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYOF myoferlin
MYRF myelin regulatory factor
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPTX2 neuronal pentraxin II
NT5E 5'-nucleotidase, ecto (CD73)
OLFM4 olfactomedin 4
PDE4DIP phosphodiesterase 4D interacting protein
PEA15 phosphoprotein enriched in astrocytes 15
PLVAP plasmalemma vesicle associated protein
POSTN periostin, osteoblast specific factor
PSAP prosaposin
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
QPCT glutaminyl-peptide cyclotransferase
RAB40B RAB40B, member RAS oncogene family
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RAP2C RAP2C, member of RAS oncogene family
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RGCC regulator of cell cycle
S100A8 S100 calcium binding protein A8
SCG2 secretogranin II
SCG5 secretogranin V
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SESN1 sestrin 1
SHOX2 short stature homeobox 2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SOCS2 suppressor of cytokine signaling 2
SOD2 superoxide dismutase 2, mitochondrial
SPON1 spondin 1, extracellular matrix protein
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SST somatostatin
SULF1 sulfatase 1
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPD52 tumor protein D52
TPP1 tripeptidyl peptidase I
TXNIP thioredoxin interacting protein
VCAN versican
VTCN1 V-set domain containing T cell activation inhibitor 1
WLS wntless Wnt ligand secretion mediator
XIST X inactive specific transcript (non-protein coding)
ZBTB18 zinc finger and BTB domain containing 18
ZFP36L1 ZFP36 ring finger protein-like 1
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
AGR2 anterior gradient 2
AK4 adenylate kinase 4
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
AQP3 aquaporin 3 (Gill blood group)
ATP9A ATPase, class II, type 9A
AURKA aurora kinase A
BAMBI BMP and activin membrane-bound inhibitor
BARD1 BRCA1 associated RING domain 1
BASP1 brain abundant, membrane attached signal protein 1
BLM Bloom syndrome, RecQ helicase-like
C2CD2 C2 calcium-dependent domain containing 2
C7 complement component 7
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN3 cyclin-dependent kinase inhibitor 3
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPA centromere protein A
CFH complement factor H
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CNOT7 CCR4-NOT transcription complex, subunit 7
CXCL12 chemokine (C-X-C motif) ligand 12
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EED embryonic ectoderm development
EIF5A eukaryotic translation initiation factor 5A
FOXO3 forkhead box O3
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45B growth arrest and DNA-damage-inducible, beta
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSPT1 G1 to S phase transition 1
GTPBP8 GTP-binding protein 8 (putative)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
HOXC10 homeobox C10
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
IGKV1-5 immunoglobulin kappa variable 1-5
ITM2A integral membrane protein 2A
JADE2 jade family PHD finger 2
JARID2 jumonji, AT rich interactive domain 2
JMJD6 jumonji domain containing 6
KANK2 KN motif and ankyrin repeat domains 2
KIAA0485 uncharacterized LOC57235
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KLHL7 kelch-like family member 7
KYNU kynureninase
LXN latexin
MARCKS myristoylated alanine-rich protein kinase C substrate
MBP myelin basic protein
MET MET proto-oncogene, receptor tyrosine kinase
NET1 neuroepithelial cell transforming 1
NFIB nuclear factor I/B
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NRIP3 nuclear receptor interacting protein 3
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
OPN3 opsin 3
PARP2 poly (ADP-ribose) polymerase 2
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTGES prostaglandin E synthase
PTMA prothymosin, alpha
PWP1 PWP1 homolog (S. cerevisiae)
RABGAP1 RAB GTPase activating protein 1
RAD51C RAD51 paralog C
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS1 regulator of G-protein signaling 1
RPL38 ribosomal protein L38
RPP25 ribonuclease P/MRP 25kDa subunit
RPP38 ribonuclease P/MRP 38kDa subunit
RPS11 ribosomal protein S11
SCEL sciellin
SEPHS1 selenophosphate synthetase 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC16A4 solute carrier family 16, member 4
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLIRP SRA stem-loop interacting RNA binding protein
SNX11 sorting nexin 11
SOBP sine oculis binding protein homolog (Drosophila)
SOX4 SRY (sex determining region Y)-box 4
SPTBN1 spectrin, beta, non-erythrocytic 1
SRSF3 serine/arginine-rich splicing factor 3
STAR steroidogenic acute regulatory protein
STOM stomatin
STXBP2 syntaxin binding protein 2
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBX2 T-box 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIPIN TIMELESS interacting protein
TMEM100 transmembrane protein 100
TMX4 thioredoxin-related transmembrane protein 4
TNC tenascin C
TSC22D2 TSC22 domain family, member 2
TSPAN8 tetraspanin 8
TTK TTK protein kinase
TUBA4A tubulin, alpha 4a
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UBE3C ubiquitin protein ligase E3C
UGDH UDP-glucose 6-dehydrogenase
ZC3H4 zinc finger CCCH-type containing 4
ZMYM2 zinc finger, MYM-type 2
ZWILCH zwilch kinetochore protein