BRD-A06352508_SB 218078_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

230 genes differentially expressed following the BRD-A06352508_SB 218078_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
AHNAK2 AHNAK nucleoprotein 2
AIF1 allograft inflammatory factor 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALOX5 arachidonate 5-lipoxygenase
ASPN asporin
ATF3 activating transcription factor 3
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
BHLHE41 basic helix-loop-helix family, member e41
BTG2 BTG family, member 2
CALD1 caldesmon 1
CD14 CD14 molecule
CD24 CD24 molecule
CD86 CD86 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CELF2 CUGBP, Elav-like family member 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLIC4 chloride intracellular channel 4
CLMN calmin (calponin-like, transmembrane)
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CST6 cystatin E/M
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCR4 chemokine (C-X-C motif) receptor 4
CYBB cytochrome b-245, beta polypeptide
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
EHF ets homologous factor
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EPCAM epithelial cell adhesion molecule
EREG epiregulin
ESR1 estrogen receptor 1
ESRP1 epithelial splicing regulatory protein 1
EVI2A ecotropic viral integration site 2A
EXPH5 exophilin 5
F3 coagulation factor III (thromboplastin, tissue factor)
FAP fibroblast activation protein, alpha
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FUBP1 far upstream element (FUSE) binding protein 1
FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase)
GADD45A growth arrest and DNA-damage-inducible, alpha
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GPM6A glycoprotein M6A
GRIA2 glutamate receptor, ionotropic, AMPA 2
H2AFY H2A histone family, member Y
HBB hemoglobin, beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL1RN interleukin 1 receptor antagonist
IL32 interleukin 32
KIF5C kinesin family member 5C
KLF9 Kruppel-like factor 9
KRT19 keratin 19, type I
KRT6B keratin 6B, type II
LDHB lactate dehydrogenase B
LMO3 LIM domain only 3 (rhombotin-like 2)
LST1 leukocyte specific transcript 1
LYZ lysozyme
MAP7 microtubule-associated protein 7
MCTP1 multiple C2 domains, transmembrane 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP11 matrix metallopeptidase 11
MT1E metallothionein 1E
MYOF myoferlin
NDP Norrie disease (pseudoglioma)
NPIPB3 nuclear pore complex interacting protein family, member B3
NT5E 5'-nucleotidase, ecto (CD73)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21
OSBPL1A oxysterol binding protein-like 1A
PBX3 pre-B-cell leukemia homeobox 3
PEA15 phosphoprotein enriched in astrocytes 15
PECAM1 platelet/endothelial cell adhesion molecule 1
PLA2G16 phospholipase A2, group XVI
PLAC8 placenta-specific 8
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PODXL podocalyxin-like
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGIS prostaglandin I2 (prostacyclin) synthase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASA4 RAS p21 protein activator 4
REG1A regenerating islet-derived 1 alpha
RGCC regulator of cell cycle
RSRP1 arginine/serine-rich protein 1
S100A9 S100 calcium binding protein A9
SCG5 secretogranin V
SCPEP1 serine carboxypeptidase 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SESN1 sestrin 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC35E2B solute carrier family 35, member E2B
SMC1A structural maintenance of chromosomes 1A
SOCS2 suppressor of cytokine signaling 2
SOX9 SRY (sex determining region Y)-box 9
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPON1 spondin 1, extracellular matrix protein
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SULF1 sulfatase 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TPD52 tumor protein D52
VAMP3 vesicle-associated membrane protein 3
VTCN1 V-set domain containing T cell activation inhibitor 1
WARS tryptophanyl-tRNA synthetase
XIST X inactive specific transcript (non-protein coding)
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZDHHC11 zinc finger, DHHC-type containing 11
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANGPT1 angiopoietin 1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AQP3 aquaporin 3 (Gill blood group)
ARFIP2 ADP-ribosylation factor interacting protein 2
ATF5 activating transcription factor 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAZ1A bromodomain adjacent to zinc finger domain, 1A
C9ORF3 chromosome 9 open reading frame 3
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CKAP4 cytoskeleton-associated protein 4
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL2A1 collagen, type II, alpha 1
COL4A5 collagen, type IV, alpha 5
CSRP1 cysteine and glycine-rich protein 1
CYTL1 cytokine-like 1
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLC1 DLC1 Rho GTPase activating protein
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4B eukaryotic translation initiation factor 4B
EIF5A eukaryotic translation initiation factor 5A
ERBB2 erb-b2 receptor tyrosine kinase 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM46C family with sequence similarity 46, member C
FGB fibrinogen beta chain
FGFR1 fibroblast growth factor receptor 1
FGG fibrinogen gamma chain
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GRWD1 glutamate-rich WD repeat containing 1
H2AFX H2A histone family, member X
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
HPCAL1 hippocalcin-like 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM2 intercellular adhesion molecule 2
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP4 insulin-like growth factor binding protein 4
IGHD immunoglobulin heavy constant delta
IGKV1-5 immunoglobulin kappa variable 1-5
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JMJD6 jumonji domain containing 6
KDM3A lysine (K)-specific demethylase 3A
KDM5D lysine (K)-specific demethylase 5D
MELK maternal embryonic leucine zipper kinase
MSX1 msh homeobox 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUP98 nucleoporin 98kDa
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PROM1 prominin 1
PRPF4 pre-mRNA processing factor 4
RAB5C RAB5C, member RAS oncogene family
RBP4 retinol binding protein 4, plasma
RBPMS RNA binding protein with multiple splicing
REEP1 receptor accessory protein 1
RGS16 regulator of G-protein signaling 16
RGS3 regulator of G-protein signaling 3
RHOB ras homolog family member B
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
S100P S100 calcium binding protein P
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLIT2 slit homolog 2 (Drosophila)
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNRPE small nuclear ribonucleoprotein polypeptide E
STOM stomatin
STXBP6 syntaxin binding protein 6 (amisyn)
SVIL supervillin
TBC1D4 TBC1 domain family, member 4
TBL1X transducin (beta)-like 1X-linked
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM2 transmembrane protein 2
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TP53BP2 tumor protein p53 binding protein 2
TRIM2 tripartite motif containing 2
TSC22D2 TSC22 domain family, member 2
ZMYM2 zinc finger, MYM-type 2