BRD-A06352508_SB 218078_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

254 genes differentially expressed following the BRD-A06352508_SB 218078_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK2 AHNAK nucleoprotein 2
ANO1 anoctamin 1, calcium activated chloride channel
AREG amphiregulin
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BTG2 BTG family, member 2
CD52 CD52 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLCA2 chloride channel accessory 2
CNOT4 CCR4-NOT transcription complex, subunit 4
CSTB cystatin B (stefin B)
CTSB cathepsin B
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYTIP cytohesin 1 interacting protein
DDIT3 DNA-damage-inducible transcript 3
DEFB4A defensin, beta 4A
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSC2 desmocollin 2
DUSP5 dual specificity phosphatase 5
EFNB2 ephrin-B2
EGR1 early growth response 1
EREG epiregulin
ESR1 estrogen receptor 1
FAM50A family with sequence similarity 50, member A
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GEM GTP binding protein overexpressed in skeletal muscle
GNPDA1 glucosamine-6-phosphate deaminase 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GREM1 gremlin 1, DAN family BMP antagonist
GUSBP11 glucuronidase, beta pseudogene 11
HBEGF heparin-binding EGF-like growth factor
HIST3H2A histone cluster 3, H2a
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IL1RN interleukin 1 receptor antagonist
IRAK1 interleukin-1 receptor-associated kinase 1
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLK10 kallikrein-related peptidase 10
KLK7 kallikrein-related peptidase 7
KRT16 keratin 16, type I
KRT6A keratin 6A, type II
LAMC2 laminin, gamma 2
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MCOLN1 mucolipin 1
MICALL1 MICAL-like 1
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MX1 MX dynamin-like GTPase 1
NCF2 neutrophil cytosolic factor 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NRIP1 nuclear receptor interacting protein 1
NUP85 nucleoporin 85kDa
NUPL1 nucleoporin like 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PI3 peptidase inhibitor 3, skin-derived
PILRB paired immunoglobin-like type 2 receptor beta
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPIF peptidylprolyl isomerase F
PPP1R15A protein phosphatase 1, regulatory subunit 15A
REEP5 receptor accessory protein 5
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RRAGD Ras-related GTP binding D
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SOCS2 suppressor of cytokine signaling 2
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR3 small proline-rich protein 3
SQSTM1 sequestosome 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UPP1 uridine phosphorylase 1
VAT1 vesicle amine transport 1
XIST X inactive specific transcript (non-protein coding)
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF185 zinc finger protein 185 (LIM domain)
ZNF330 zinc finger protein 330

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAM10 ADAM metallopeptidase domain 10
ADIRF adipogenesis regulatory factor
AGR2 anterior gradient 2
AKR1C3 aldo-keto reductase family 1, member C3
AMIGO2 adhesion molecule with Ig-like domain 2
ANPEP alanyl (membrane) aminopeptidase
APOH apolipoprotein H (beta-2-glycoprotein I)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
B3GNT1
BICC1 BicC family RNA binding protein 1
C5 complement component 5
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CD200 CD200 molecule
CD99 CD99 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CFI complement factor I
CNN3 calponin 3, acidic
COL11A1 collagen, type XI, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL5A1 collagen, type V, alpha 1
COL6A3 collagen, type VI, alpha 3
CRABP1 cellular retinoic acid binding protein 1
DCN decorin
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYD dihydropyrimidine dehydrogenase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELOVL5 ELOVL fatty acid elongase 5
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ETV1 ets variant 1
FBLN1 fibulin 1
FBN1 fibrillin 1
FCGBP Fc fragment of IgG binding protein
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FN1 fibronectin 1
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GLRX glutaredoxin (thioltransferase)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPC3 glypican 3
GSTA1 glutathione S-transferase alpha 1
GYG2 glycogenin 2
HEG1 heart development protein with EGF-like domains 1
HES1 hes family bHLH transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
IGFBP1 insulin-like growth factor binding protein 1
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IL6ST interleukin 6 signal transducer
KLHDC2 kelch domain containing 2
LAMA4 laminin, alpha 4
LAMB1 laminin, beta 1
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LIMCH1 LIM and calponin homology domains 1
LOX lysyl oxidase
LRRC17 leucine rich repeat containing 17
MAGED1 melanoma antigen family D1
MAOA monoamine oxidase A
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MMP9 matrix metallopeptidase 9
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NID2 nidogen 2 (osteonidogen)
NNMT nicotinamide N-methyltransferase
NPY1R neuropeptide Y receptor Y1
NQO1 NAD(P)H dehydrogenase, quinone 1
NUAK1 NUAK family, SNF1-like kinase, 1
NUPR1 nuclear protein, transcriptional regulator, 1
P3H2 prolyl 3-hydroxylase 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFD platelet derived growth factor D
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG10 paternally expressed 10
PFDN4 prefoldin subunit 4
PHGDH phosphoglycerate dehydrogenase
PIGK phosphatidylinositol glycan anchor biosynthesis, class K
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLP1 proteolipid protein 1
PLSCR4 phospholipid scramblase 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PPAP2A phosphatidic acid phosphatase type 2A
PRSS23 protease, serine, 23
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PXDN peroxidasin
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RHOBTB3 Rho-related BTB domain containing 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS4Y1 ribosomal protein S4, Y-linked 1
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
SCARB1 scavenger receptor class B, member 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCRG1 stimulator of chondrogenesis 1
SDC2 syndecan 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGCE sarcoglycan, epsilon
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SOBP sine oculis binding protein homolog (Drosophila)
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX10 SRY (sex determining region Y)-box 10
SPA17 sperm autoantigenic protein 17
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPDEF SAM pointed domain containing ETS transcription factor
SPP1 secreted phosphoprotein 1
TAGLN transgelin
TCF4 transcription factor 4
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM47 transmembrane protein 47
TMEM50A transmembrane protein 50A
TMSB15A thymosin beta 15a
TMX4 thioredoxin-related transmembrane protein 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS3 tensin 3
TPM1 tropomyosin 1 (alpha)
TRAK2 trafficking protein, kinesin binding 2
TSPAN8 tetraspanin 8
TUSC3 tumor suppressor candidate 3
UGDH UDP-glucose 6-dehydrogenase
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VAV3 vav 3 guanine nucleotide exchange factor
WASF1 WAS protein family, member 1
WDR61 WD repeat domain 61
WNT5A wingless-type MMTV integration site family, member 5A
WWTR1 WW domain containing transcription regulator 1