BRD-A06352508_SB 218078_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

226 genes differentially expressed following the BRD-A06352508_SB 218078_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ANKRD10 ankyrin repeat domain 10
APLP1 amyloid beta (A4) precursor-like protein 1
AQP1 aquaporin 1 (Colton blood group)
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASCL1 achaete-scute family bHLH transcription factor 1
AZU1 azurocidin 1
BCHE butyrylcholinesterase
BMP2 bone morphogenetic protein 2
CA2 carbonic anhydrase II
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD14 CD14 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD93 CD93 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CKB creatine kinase, brain
COL3A1 collagen, type III, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CYB561 cytochrome b561
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DEFA4 defensin, alpha 4, corticostatin
DHCR24 24-dehydrocholesterol reductase
DPYSL3 dihydropyrimidinase-like 3
DTX4 deltex 4, E3 ubiquitin ligase
ELANE elastase, neutrophil expressed
FBXL7 F-box and leucine-rich repeat protein 7
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR3 fibroblast growth factor receptor 3
GLUL glutamate-ammonia ligase
GPM6A glycoprotein M6A
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
HBB hemoglobin, beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGN5 high mobility group nucleosome binding domain 5
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
LDB2 LIM domain binding 2
LPCAT1 lysophosphatidylcholine acyltransferase 1
MEIS2 Meis homeobox 2
METRN meteorin, glial cell differentiation regulator
MMP9 matrix metallopeptidase 9
MNDA myeloid cell nuclear differentiation antigen
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
MSLN mesothelin
MXRA5 matrix-remodelling associated 5
NDP Norrie disease (pseudoglioma)
NLGN4X neuroligin 4, X-linked
PBX1 pre-B-cell leukemia homeobox 1
PCDH17 protocadherin 17
PCLO piccolo presynaptic cytomatrix protein
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE4DIP phosphodiesterase 4D interacting protein
PRKCB protein kinase C, beta
PRTN3 proteinase 3
PTGIS prostaglandin I2 (prostacyclin) synthase
PTPRO protein tyrosine phosphatase, receptor type, O
RAP2C RAP2C, member of RAS oncogene family
RGCC regulator of cell cycle
RIMS3 regulating synaptic membrane exocytosis 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP4 secreted frizzled-related protein 4
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPARCL1 SPARC-like 1 (hevin)
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON1 spondin 1, extracellular matrix protein
STS steroid sulfatase (microsomal), isozyme S
SULF1 sulfatase 1
TDO2 tryptophan 2,3-dioxygenase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNNT1 troponin T type 1 (skeletal, slow)
TPD52 tumor protein D52
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN12 tetraspanin 12
WT1 Wilms tumor 1
ZG16 zymogen granule protein 16
ZNF264 zinc finger protein 264

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ADGRG2 adhesion G protein-coupled receptor G2
ADK adenosine kinase
ADM adrenomedullin
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALCAM activated leukocyte cell adhesion molecule
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMD1 adenosylmethionine decarboxylase 1
ANXA1 annexin A1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BLMH bleomycin hydrolase
C16ORF45 chromosome 16 open reading frame 45
C9ORF3 chromosome 9 open reading frame 3
CBFB core-binding factor, beta subunit
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CD58 CD58 molecule
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
COL9A3 collagen, type IX, alpha 3
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRY1 cryptochrome circadian clock 1
CRYAB crystallin, alpha B
CYBA cytochrome b-245, alpha polypeptide
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DICER1 dicer 1, ribonuclease type III
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DLG1 discs, large homolog 1 (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP5 dual specificity phosphatase 5
ECD ecdysoneless homolog (Drosophila)
EGFR epidermal growth factor receptor
EMP1 epithelial membrane protein 1
EMP3 epithelial membrane protein 3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOSL1 FOS-like antigen 1
FZD7 frizzled class receptor 7
GCLM glutamate-cysteine ligase, modifier subunit
GLIPR1 GLI pathogenesis-related 1
GLS glutaminase
GOLGA8A golgin A8 family, member A
GPX3 glutathione peroxidase 3
GRB10 growth factor receptor-bound protein 10
GTPBP8 GTP-binding protein 8 (putative)
H2AFX H2A histone family, member X
HK1 hexokinase 1
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGF1R insulin-like growth factor 1 receptor
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGFBP4 insulin-like growth factor binding protein 4
IL6 interleukin 6
INPP1 inositol polyphosphate-1-phosphatase
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KANK1 KN motif and ankyrin repeat domains 1
KIAA1033 KIAA1033
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT5 keratin 5, type II
KRT7 keratin 7, type II
LAMP5 lysosomal-associated membrane protein family, member 5
LOX lysyl oxidase
LPL lipoprotein lipase
LRP4 low density lipoprotein receptor-related protein 4
LXN latexin
LY6D lymphocyte antigen 6 complex, locus D
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MET MET proto-oncogene, receptor tyrosine kinase
MMP7 matrix metallopeptidase 7
MT1X metallothionein 1X
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO10 myosin X
NAV2 neuron navigator 2
NFIL3 nuclear factor, interleukin 3 regulated
NMB neuromedin B
NQO1 NAD(P)H dehydrogenase, quinone 1
NUP98 nucleoporin 98kDa
OXTR oxytocin receptor
PAX8 paired box 8
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM4 PDZ and LIM domain 4
PFKP phosphofructokinase, platelet
PHF11 PHD finger protein 11
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLCB4 phospholipase C, beta 4
PLIN2 perilipin 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPAP2B phosphatidic acid phosphatase type 2B
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PROM1 prominin 1
PTDSS1 phosphatidylserine synthase 1
PTX3 pentraxin 3, long
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RHOB ras homolog family member B
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A2 S100 calcium binding protein A2
SFN stratifin
SFRP1 secreted frizzled-related protein 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC43A3 solute carrier family 43, member 3
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMAD3 SMAD family member 3
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPHK1 sphingosine kinase 1
SYNM synemin, intermediate filament protein
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D4 TBC1 domain family, member 4
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM2 transmembrane protein 2
TNC tenascin C
TRAK2 trafficking protein, kinesin binding 2
TRAM2 translocation associated membrane protein 2
TSPYL5 TSPY-like 5
WSB1 WD repeat and SOCS box containing 1
WTAP Wilms tumor 1 associated protein
ZW10 zw10 kinetochore protein