BRD-A06352508_SB 218078_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

244 genes differentially expressed following the BRD-A06352508_SB 218078_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK2 AHNAK nucleoprotein 2
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
CCL20 chemokine (C-C motif) ligand 20
CCND1 cyclin D1
CD163 CD163 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL4A6 collagen, type IV, alpha 6
CSTA cystatin A (stefin A)
CTSK cathepsin K
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DUSP3 dual specificity phosphatase 3
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EREG epiregulin
FAM129A family with sequence similarity 129, member A
FAS Fas cell surface death receptor
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GAL galanin/GMAP prepropeptide
GCH1 GTP cyclohydrolase 1
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GNPDA1 glucosamine-6-phosphate deaminase 1
HAL histidine ammonia-lyase
HDAC9 histone deacetylase 9
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IL13RA2 interleukin 13 receptor, alpha 2
IL2RG interleukin 2 receptor, gamma
INPP1 inositol polyphosphate-1-phosphatase
INSM1 insulinoma-associated 1
KCTD12 potassium channel tetramerization domain containing 12
KLF5 Kruppel-like factor 5 (intestinal)
KRT17 keratin 17, type I
KRT81 keratin 81, type II
KYNU kynureninase
LGALS3 lectin, galactoside-binding, soluble, 3
MAGEA3 melanoma antigen family A3
MBP myelin basic protein
MCTP1 multiple C2 domains, transmembrane 1
MMP9 matrix metallopeptidase 9
NCF2 neutrophil cytosolic factor 2
NELL2 NEL-like 2 (chicken)
NOP2 NOP2 nucleolar protein
PERP PERP, TP53 apoptosis effector
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLXNC1 plexin C1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNP purine nucleoside phosphorylase
PRNP prion protein
PRRC2C proline-rich coiled-coil 2C
RBP4 retinol binding protein 4, plasma
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RRAGD Ras-related GTP binding D
RSL1D1 ribosomal L1 domain containing 1
RUNX3 runt-related transcription factor 3
SLC35F2 solute carrier family 35, member F2
SOCS2 suppressor of cytokine signaling 2
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SQSTM1 sequestosome 1
STK10 serine/threonine kinase 10
TDO2 tryptophan 2,3-dioxygenase
TRIM2 tripartite motif containing 2
VNN1 vanin 1
ZNF91 zinc finger protein 91
ZYX zyxin

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ABHD4 abhydrolase domain containing 4
ACSF2 acyl-CoA synthetase family member 2
ADAM10 ADAM metallopeptidase domain 10
ADAM12 ADAM metallopeptidase domain 12
ADD3 adducin 3 (gamma)
ADGRG1 adhesion G protein-coupled receptor G1
ALCAM activated leukocyte cell adhesion molecule
ALDOC aldolase C, fructose-bisphosphate
APOD apolipoprotein D
ARL3 ADP-ribosylation factor-like 3
BASP1 brain abundant, membrane attached signal protein 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CALU calumenin
CD59 CD59 molecule, complement regulatory protein
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEMIP cell migration inducing protein, hyaluronan binding
CETN2 centrin, EF-hand protein, 2
CFLAR CASP8 and FADD-like apoptosis regulator
CKAP4 cytoskeleton-associated protein 4
CLIC3 chloride intracellular channel 3
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSRP2 cysteine and glycine-rich protein 2
CXCL12 chemokine (C-X-C motif) ligand 12
CYTH1 cytohesin 1
DCXR dicarbonyl/L-xylulose reductase
DEPTOR DEP domain containing MTOR-interacting protein
DKK3 dickkopf WNT signaling pathway inhibitor 3
DSTN destrin (actin depolymerizing factor)
EAPP E2F-associated phosphoprotein
ECI2 enoyl-CoA delta isomerase 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EHD3 EH-domain containing 3
ELOVL5 ELOVL fatty acid elongase 5
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
ERMP1 endoplasmic reticulum metallopeptidase 1
EVL Enah/Vasp-like
FABP7 fatty acid binding protein 7, brain
FBN1 fibrillin 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FKBP14 FK506 binding protein 14, 22 kDa
FN1 fibronectin 1
FZD7 frizzled class receptor 7
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPX3 glutathione peroxidase 3
GREB1 growth regulation by estrogen in breast cancer 1
GSTA4 glutathione S-transferase alpha 4
HEG1 heart development protein with EGF-like domains 1
HNMT histamine N-methyltransferase
HOXA5 homeobox A5
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDI1 isopentenyl-diphosphate delta isomerase 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
IL1R1 interleukin 1 receptor, type I
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAMP1 lysosomal-associated membrane protein 1
LBH limb bud and heart development
LDLR low density lipoprotein receptor
LEF1 lymphoid enhancer-binding factor 1
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LIPA lipase A, lysosomal acid, cholesterol esterase
LMCD1 LIM and cysteine-rich domains 1
LOC730101 uncharacterized LOC730101
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
LRP4 low density lipoprotein receptor-related protein 4
MAGED1 melanoma antigen family D1
MAGED2 melanoma antigen family D2
MAGEH1 melanoma antigen family H1
MAOA monoamine oxidase A
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
MARCKS myristoylated alanine-rich protein kinase C substrate
MBNL2 muscleblind-like splicing regulator 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MRPS16 mitochondrial ribosomal protein S16
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
MYLK myosin light chain kinase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NPR3 natriuretic peptide receptor 3
NREP neuronal regeneration related protein
OLFML3 olfactomedin-like 3
OPCML opioid binding protein/cell adhesion molecule-like
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PHKB phosphorylase kinase, beta
PLAT plasminogen activator, tissue
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPAP2B phosphatidic acid phosphatase type 2B
PRSS23 protease, serine, 23
PSAP prosaposin
PTPRD protein tyrosine phosphatase, receptor type, D
QPRT quinolinate phosphoribosyltransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RBP1 retinol binding protein 1, cellular
RBPMS RNA binding protein with multiple splicing
RHOB ras homolog family member B
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SDC2 syndecan 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SIDT2 SID1 transmembrane family, member 2
SKAP2 src kinase associated phosphoprotein 2
SKP1 S-phase kinase-associated protein 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMYD3 SET and MYND domain containing 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPTSSA serine palmitoyltransferase, small subunit A
STC1 stanniocalcin 1
STMN1 stathmin 1
TCF4 transcription factor 4
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS1 thrombospondin 1
TMEM14A transmembrane protein 14A
TMEM47 transmembrane protein 47
TMSB15A thymosin beta 15a
TPGS2 tubulin polyglutamylase complex subunit 2
TPM1 tropomyosin 1 (alpha)
TRAM2 translocation associated membrane protein 2
TSPAN13 tetraspanin 13
TXNDC9 thioredoxin domain containing 9
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAN versican
VKORC1 vitamin K epoxide reductase complex, subunit 1
VLDLR very low density lipoprotein receptor
WNT5A wingless-type MMTV integration site family, member 5A
YPEL5 yippee-like 5 (Drosophila)
ZCCHC24 zinc finger, CCHC domain containing 24
ZMIZ1 zinc finger, MIZ-type containing 1