BRD-A06352418_TERFENADINE_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

69 genes differentially expressed following the BRD-A06352418_TERFENADINE_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACTG2 actin, gamma 2, smooth muscle, enteric
ALDOC aldolase C, fructose-bisphosphate
CETN2 centrin, EF-hand protein, 2
CLIC4 chloride intracellular channel 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
ELOVL6 ELOVL fatty acid elongase 6
FADS2 fatty acid desaturase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FOXO3 forkhead box O3
GJA1 gap junction protein, alpha 1, 43kDa
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
KRT14 keratin 14, type I
LDLR low density lipoprotein receptor
LIPA lipase A, lysosomal acid, cholesterol esterase
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MME membrane metallo-endopeptidase
MSMB microseminoprotein, beta-
MSMO1 methylsterol monooxygenase 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
PPAP2A phosphatidic acid phosphatase type 2A
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SORBS1 sorbin and SH3 domain containing 1
SQLE squalene epoxidase
STXBP1 syntaxin binding protein 1
TM7SF2 transmembrane 7 superfamily member 2
VGLL4 vestigial-like family member 4

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
AUTS2 autism susceptibility candidate 2
C1ORF115 chromosome 1 open reading frame 115
CDC25A cell division cycle 25A
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
DKK1 dickkopf WNT signaling pathway inhibitor 1
EFHD1 EF-hand domain family, member D1
EIF5A eukaryotic translation initiation factor 5A
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
HIST1H4C histone cluster 1, H4c
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMMR hyaluronan-mediated motility receptor (RHAMM)
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
LIG1 ligase I, DNA, ATP-dependent
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
NCAPH non-SMC condensin I complex, subunit H
PBK PDZ binding kinase
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLK1 polo-like kinase 1
PTTG1 pituitary tumor-transforming 1
STMN1 stathmin 1
TPX2 TPX2, microtubule-associated
UBE2C ubiquitin-conjugating enzyme E2C
ZWINT ZW10 interacting kinetochore protein