BRD-A06352418_TERFENADINE_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-A06352418_TERFENADINE_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACSL3 acyl-CoA synthetase long-chain family member 3
AHR aryl hydrocarbon receptor
ANXA3 annexin A3
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
CARS cysteinyl-tRNA synthetase
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CETN2 centrin, EF-hand protein, 2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC4 chloride intracellular channel 4
CSTA cystatin A (stefin A)
CSTB cystatin B (stefin B)
CTH cystathionine gamma-lyase
CTSH cathepsin H
CXCL14 chemokine (C-X-C motif) ligand 14
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPYSL2 dihydropyrimidinase-like 2
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP3 dual specificity phosphatase 3
EBP emopamil binding protein (sterol isomerase)
EPHB2 EPH receptor B2
F13A1 coagulation factor XIII, A1 polypeptide
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAS Fas cell surface death receptor
FASN fatty acid synthase
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FOXO3 forkhead box O3
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H')
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
L1CAM L1 cell adhesion molecule
LDLR low density lipoprotein receptor
LPAR6 lysophosphatidic acid receptor 6
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MKNK2 MAP kinase interacting serine/threonine kinase 2
MME membrane metallo-endopeptidase
MSMO1 methylsterol monooxygenase 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
PANK3 pantothenate kinase 3
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSAT1 phosphoserine aminotransferase 1
RRAGC Ras-related GTP binding C
SARS seryl-tRNA synthetase
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEC24D SEC24 family member D
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SQLE squalene epoxidase
SQSTM1 sequestosome 1
SREBF2 sterol regulatory element binding transcription factor 2
SYBU syntabulin (syntaxin-interacting)
TARS threonyl-tRNA synthetase
TCTN1 tectonic family member 1
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
XPOT exportin, tRNA

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AREG amphiregulin
ASRGL1 asparaginase like 1
C21ORF59 chromosome 21 open reading frame 59
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CKB creatine kinase, brain
CSK c-src tyrosine kinase
CTPS1 CTP synthase 1
EHD3 EH-domain containing 3
EIF5A eukaryotic translation initiation factor 5A
FGA fibrinogen alpha chain
GATA2 GATA binding protein 2
GPX3 glutathione peroxidase 3
HIST1H4C histone cluster 1, H4c
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
NR4A2 nuclear receptor subfamily 4, group A, member 2
ODC1 ornithine decarboxylase 1
PEG3 paternally expressed 3
PLAGL1 pleiomorphic adenoma gene-like 1
PRKACB protein kinase, cAMP-dependent, catalytic, beta
RAB31 RAB31, member RAS oncogene family
RBP1 retinol binding protein 1, cellular
REEP1 receptor accessory protein 1
RGS2 regulator of G-protein signaling 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCGB2A1 secretoglobin, family 2A, member 1
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
TFPI2 tissue factor pathway inhibitor 2
WT1 Wilms tumor 1