BRD-A06352418_TERFENADINE_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

236 genes differentially expressed following the BRD-A06352418_TERFENADINE_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AMDHD2 amidohydrolase domain containing 2
AQP9 aquaporin 9
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BCL2A1 BCL2-related protein A1
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CST1 cystatin SN
CTSA cathepsin A
CXCL8 chemokine (C-X-C motif) ligand 8
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
EGFL6 EGF-like-domain, multiple 6
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FKBP14 FK506 binding protein 14, 22 kDa
G6PD glucose-6-phosphate dehydrogenase
GNPDA1 glucosamine-6-phosphate deaminase 1
GREM1 gremlin 1, DAN family BMP antagonist
GRN granulin
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HK2 hexokinase 2
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HPCAL1 hippocalcin-like 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
IRF9 interferon regulatory factor 9
ISG20 interferon stimulated exonuclease gene 20kDa
KLHL24 kelch-like family member 24
LAMP2 lysosomal-associated membrane protein 2
LDLR low density lipoprotein receptor
LIPA lipase A, lysosomal acid, cholesterol esterase
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LTB lymphotoxin beta (TNF superfamily, member 3)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGED2 melanoma antigen family D2
MAP7 microtubule-associated protein 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
NAMPT nicotinamide phosphoribosyltransferase
NCF2 neutrophil cytosolic factor 2
NEU1 sialidase 1 (lysosomal sialidase)
NPC1 Niemann-Pick disease, type C1
NQO1 NAD(P)H dehydrogenase, quinone 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUPR1 nuclear protein, transcriptional regulator, 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PPAP2B phosphatidic acid phosphatase type 2B
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RHOQ ras homolog family member Q
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDCBP syndecan binding protein (syntenin)
SERINC3 serine incorporator 3
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SNN stannin
SOD2 superoxide dismutase 2, mitochondrial
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SQLE squalene epoxidase
SQSTM1 sequestosome 1
TNIP1 TNFAIP3 interacting protein 1
TPP1 tripeptidyl peptidase I
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a
TXNRD1 thioredoxin reductase 1
UGDH UDP-glucose 6-dehydrogenase
VAT1 vesicle amine transport 1
VEGFA vascular endothelial growth factor A
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BAG2 BCL2-associated athanogene 2
BARD1 BRCA1 associated RING domain 1
BIRC5 baculoviral IAP repeat containing 5
BLM Bloom syndrome, RecQ helicase-like
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C7 complement component 7
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CD44 CD44 molecule (Indian blood group)
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
COL3A1 collagen, type III, alpha 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTPS1 CTP synthase 1
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DMD dystrophin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FSTL1 follistatin-like 1
GAS1 growth arrest-specific 1
GATA2 GATA binding protein 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HELLS helicase, lymphoid-specific
HES1 hes family bHLH transcription factor 1
HJURP Holliday junction recognition protein
HMGB1 high mobility group box 1
HOPX HOP homeobox
HOXC6 homeobox C6
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
IGFBP7 insulin-like growth factor binding protein 7
ITM2A integral membrane protein 2A
KIAA0101 KIAA0101
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF2C kinesin family member 2C
LIG1 ligase I, DNA, ATP-dependent
LYPD1 LY6/PLAUR domain containing 1
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG2 non-SMC condensin II complex, subunit G2
NR2F2 nuclear receptor subfamily 2, group F, member 2
NTS neurotensin
NUP210 nucleoporin 210kDa
OLFM1 olfactomedin 1
PA2G4 proliferation-associated 2G4, 38kDa
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKD3 protein kinase D3
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTMA prothymosin, alpha
RACGAP1 Rac GTPase activating protein 1
RAD54B RAD54 homolog B (S. cerevisiae)
RBP1 retinol binding protein 1, cellular
RBPMS RNA binding protein with multiple splicing
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RGS2 regulator of G-protein signaling 2
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMC1A structural maintenance of chromosomes 1A
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SNRPF small nuclear ribonucleoprotein polypeptide F
SORBS1 sorbin and SH3 domain containing 1
SRSF1 serine/arginine-rich splicing factor 1
SRSF3 serine/arginine-rich splicing factor 3
SRSF6 serine/arginine-rich splicing factor 6
STIL SCL/TAL1 interrupting locus
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TIMELESS timeless circadian clock
TMEM47 transmembrane protein 47
TMEM70 transmembrane protein 70
TMPO thymopoietin
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UNG uracil-DNA glycosylase
USP1 ubiquitin specific peptidase 1
VRK1 vaccinia related kinase 1
WEE1 WEE1 G2 checkpoint kinase
ZWINT ZW10 interacting kinetochore protein