BRD-A06352418_TERFENADINE_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

155 genes differentially expressed following the BRD-A06352418_TERFENADINE_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BCL3 B-cell CLL/lymphoma 3
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C8ORF4 chromosome 8 open reading frame 4
C9ORF3 chromosome 9 open reading frame 3
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEMIP cell migration inducing protein, hyaluronan binding
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIAPIN1 cytokine induced apoptosis inhibitor 1
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP5 dual specificity phosphatase 5
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR3 early growth response 3
EHD1 EH-domain containing 1
EMP1 epithelial membrane protein 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO3 forkhead box O3
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
H2BFS H2B histone family, member S (pseudogene)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST1H2BK histone cluster 1, H2bk
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
ICAM1 intercellular adhesion molecule 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
IER5 immediate early response 5
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KIAA0226L KIAA0226-like
KLF6 Kruppel-like factor 6
KRT14 keratin 14, type I
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
LIMCH1 LIM and calponin homology domains 1
LPIN1 lipin 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MGLL monoglyceride lipase
MSMO1 methylsterol monooxygenase 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH2NL notch 2 N-terminal like
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PAEP progestagen-associated endometrial protein
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PPAP2B phosphatidic acid phosphatase type 2B
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SAMD4A sterile alpha motif domain containing 4A
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG5 secretogranin V
SDC4 syndecan 4
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC38A1 solute carrier family 38, member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SOD2 superoxide dismutase 2, mitochondrial
SQLE squalene epoxidase
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNNT1 troponin T type 1 (skeletal, slow)
TSC22D1 TSC22 domain family, member 1
TUFT1 tuftelin 1
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANPEP alanyl (membrane) aminopeptidase
ANXA1 annexin A1
ANXA6 annexin A6
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASRGL1 asparaginase like 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCND2 cyclin D2
CCNF cyclin F
CD9 CD9 molecule
CDC20 cell division cycle 20
COL1A2 collagen, type I, alpha 2
COL6A3 collagen, type VI, alpha 3
COPS7A COP9 signalosome subunit 7A
DCXR dicarbonyl/L-xylulose reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ECI2 enoyl-CoA delta isomerase 2
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
FHOD3 formin homology 2 domain containing 3
GPX3 glutathione peroxidase 3
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HMGN5 high mobility group nucleosome binding domain 5
HOXB7 homeobox B7
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA6 integrin, alpha 6
KRT18 keratin 18, type I
LAPTM5 lysosomal protein transmembrane 5
MAGED1 melanoma antigen family D1
MXRA7 matrix-remodelling associated 7
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
PCCB propionyl CoA carboxylase, beta polypeptide
PDZD8 PDZ domain containing 8
PFN2 profilin 2
PON2 paraoxonase 2
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PRSS23 protease, serine, 23
PSPH phosphoserine phosphatase
RPA3 replication protein A3, 14kDa
SEPP1 selenoprotein P, plasma, 1
SPEN spen family transcriptional repressor
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TPM1 tropomyosin 1 (alpha)
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)