BRD-A06276885_N-Benzylnaltrindole hydrochloride_SKB_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

73 genes differentially expressed following the BRD-A06276885_N-Benzylnaltrindole hydrochloride_SKB_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALCAM activated leukocyte cell adhesion molecule
BHLHE41 basic helix-loop-helix family, member e41
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
EREG epiregulin
FABP4 fatty acid binding protein 4, adipocyte
FADS1 fatty acid desaturase 1
HIP1 huntingtin interacting protein 1
HIST1H2AC histone cluster 1, H2ac
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
INSIG1 insulin induced gene 1
LEPR leptin receptor
MLF1 myeloid leukemia factor 1
MSMO1 methylsterol monooxygenase 1
NEBL nebulette
NEU1 sialidase 1 (lysosomal sialidase)
NPC1 Niemann-Pick disease, type C1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SQLE squalene epoxidase
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
TGM2 transglutaminase 2
XPOT exportin, tRNA
ZNF652 zinc finger protein 652

decreased expression

Symbol Name
ADM adrenomedullin
CCL2 chemokine (C-C motif) ligand 2
CCND2 cyclin D2
CDC20 cell division cycle 20
CDC45 cell division cycle 45
CDK1 cyclin-dependent kinase 1
CLC Charcot-Leyden crystal galectin
CLTB clathrin, light chain B
COL1A2 collagen, type I, alpha 2
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
ECM1 extracellular matrix protein 1
FGFR3 fibroblast growth factor receptor 3
GAGE3 G antigen 3
GATA3 GATA binding protein 3
GBP1 guanylate binding protein 1, interferon-inducible
H2AFX H2A histone family, member X
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
LOXL1 lysyl oxidase-like 1
MAGEA3 melanoma antigen family A3
MMP9 matrix metallopeptidase 9
MT1E metallothionein 1E
NRGN neurogranin (protein kinase C substrate, RC3)
NUSAP1 nucleolar and spindle associated protein 1
NXN nucleoredoxin
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PFN2 profilin 2
RANBP1 RAN binding protein 1
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
UBE2C ubiquitin-conjugating enzyme E2C